Seroprevalence and correlates of hepatitis A among HIV-negative American men who have sex with men

Stephanie R. Bialek, Vaughn Barry, Beth P. Bell, Linda A. Valleroy, Stephanie Behel, Duncan A. MacKellar, Gina Secura, Hanne Thiede, Willi McFarland, Wesley L. Ford, Trista A. Bingham, Douglas A. Shehan, David D. Celentano

Research output: Contribution to journalArticlepeer-review


Background: Hepatitis A outbreaks are well documented among men who have sex with men (MSM). This analysis examines characteristics associated with hepatitis A virus (HAV) infection among a large group of young adult MSM from five USA cities. Methods: The Young Men's Survey was a cross-sectional prevalence study of HIV infection and related behavioural risk factors among MSM aged 15-29 years during 1994-2000. Serum specimens from HIV-negative participants were retrospectively tested for antibodies to HAV (anti-HAV). Data were stratified by ethnicity and analysed with logistic regression. Results: Overall anti-HAV prevalence was 18.4% among the 2708 participants, and varied by ethnicity from 6.9 to 45.3% and was highest among Hispanic and Asian men (P < 0.001). Prevalence increased with age across all racial/ethnic groups. Among white men, anti-HAV positivity was associated with having 20 or more lifetime male sex partners for those aged 15-22 years (adjusted odds ratio (AOR)=2.1, 95% confidence interval (CI)=1.0-4.1) and ever having had unprotected anal sex for those aged 23-29 years (AOR=2.4, 95% CI=1.2-4.5). Conclusions: Factors associated with a history of HAV infection among MSM in non-outbreak settings are probably similar to those among non-MSM. MSM are still at risk for HAV infection as a result of outbreaks occurring in MSM communities. Additional studies of hepatitis A vaccination coverage are needed to determine if strategies to vaccinate MSM are adequate.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalSexual Health
Issue number3
StatePublished - 2011


  • MSM
  • USA
  • hepatitis A
  • hepatitis A vaccination
  • prevalence
  • young men's study

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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