TY - JOUR
T1 - Seropositivity for HIV and the development of AIDS or AIDS related condition
T2 - Three year follow up of the San Francisco General Hospital cohort
AU - Moss, Andrew R.
AU - Bacchetti, Peter
AU - Osmond, Dennis
AU - Krampf, Walter
AU - Chaisson, Richard E.
AU - Stites, Daniel
AU - Wilber, Judith
AU - Allain, Jean Pierre
AU - Carlson, James
N1 - Funding Information:
We thank the men who made this study possible by participating in it; Rita Meakin, Elliot Ross, and James Halsey for long and effective service; Eileen O'Connell; Dr Paul Volberding and the staff of the AIDS clinic at San Francisco General Hospital; Dr Michael Leuther, Abbott Laboratories; Dr John Greenspan and the staff of the AIDS serum bank at UCSF; and Dr Herbert Perkins, Irwin Memorial Blood Bank. This work was supported by funds provided by the State of California and allocated on the recommendation of the Universitywide Task Force on AIDS.
PY - 1988/3
Y1 - 1988/3
N2 - The three year actuarial progression rate to the acquired immune deficiency syndrome (AIDS) in a cohort of men in San Francisco who were seropositive for the human immunodeficiency virus (HIV) was 22%. An additional 26 (19%) developed AIDS related conditions. |32 Microglobulin concentration, packed cell volume, HIV p24 antigenaemia, and the proportion and number of T4 lymphocytes each independently predicted progression to AIDS. |32 Microglobulin was the most powerful predictor. The 111 subjects tested who were normal by all predictors (40%) had a three year progression rate of 7%, and the 68 subjects who were abnormal by two or more predictors (24%) had a progression rate of 57%. Two thirds of all men who progressed to AIDS were in the last group.
AB - The three year actuarial progression rate to the acquired immune deficiency syndrome (AIDS) in a cohort of men in San Francisco who were seropositive for the human immunodeficiency virus (HIV) was 22%. An additional 26 (19%) developed AIDS related conditions. |32 Microglobulin concentration, packed cell volume, HIV p24 antigenaemia, and the proportion and number of T4 lymphocytes each independently predicted progression to AIDS. |32 Microglobulin was the most powerful predictor. The 111 subjects tested who were normal by all predictors (40%) had a three year progression rate of 7%, and the 68 subjects who were abnormal by two or more predictors (24%) had a progression rate of 57%. Two thirds of all men who progressed to AIDS were in the last group.
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U2 - 10.1136/bmj.296.6624.745
DO - 10.1136/bmj.296.6624.745
M3 - Article
C2 - 3126959
AN - SCOPUS:0023865054
SN - 0959-8146
VL - 296
SP - 745
EP - 750
JO - British Medical Journal
JF - British Medical Journal
IS - 6624
ER -