Seropositivity for HIV and the development of AIDS or AIDS related condition: Three year follow up of the San Francisco General Hospital cohort

Andrew R. Moss, Peter Bacchetti, Dennis Osmond, Walter Krampf, Richard E. Chaisson, Daniel Stites, Judith Wilber, Jean Pierre Allain, James Carlson

Research output: Contribution to journalArticle

Abstract

The three year actuarial progression rate to the acquired immune deficiency syndrome (AIDS) in a cohort of men in San Francisco who were seropositive for the human immunodeficiency virus (HIV) was 22%. An additional 26 (19%) developed AIDS related conditions. |32 Microglobulin concentration, packed cell volume, HIV p24 antigenaemia, and the proportion and number of T4 lymphocytes each independently predicted progression to AIDS. |32 Microglobulin was the most powerful predictor. The 111 subjects tested who were normal by all predictors (40%) had a three year progression rate of 7%, and the 68 subjects who were abnormal by two or more predictors (24%) had a progression rate of 57%. Two thirds of all men who progressed to AIDS were in the last group.

Original languageEnglish (US)
Pages (from-to)745-750
Number of pages6
JournalBritish Medical Journal (Clinical research ed.)
Volume296
Issue number6624
DOIs
StatePublished - Mar 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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