Serological Measures of Trachoma Transmission Intensity

Diana L. Martin, Ryan Wiegand, Brook Goodhew, Patrick Lammie, Carolyn M. Black, Sheila West, Charlotte A. Gaydos, Laura Dize, Harran Mkocha, Mabula Kasubi, Manoj Gambhir

Research output: Contribution to journalArticlepeer-review

Abstract

Ocular infection with Chlamydia trachomatis can lead to trachoma, a leading infectious cause of blindness. Trachoma is targeted for elimination by 2020. Clinical grading for ocular disease is currently used for evaluating trachoma elimination programs, but serological surveillance can be a sensitive measure of disease transmission and provide a more objective testing strategy than clinical grading. We calculated the basic reproduction number from serological data in settings with high, medium, and low disease transmission based on clinical disease. The data showed a striking relationship between age seroprevalence and clinical data, demonstrating the proof-of-principle that age seroprevalence predicts transmission rates and therefore could be used as an indicator of decreased transmission of ocular trachoma.

Original languageEnglish (US)
Article number18532
JournalScientific reports
Volume5
DOIs
StatePublished - Dec 21 2015

ASJC Scopus subject areas

  • General

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