Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: A case-control study

Marcel E. Curlin, Farah Cassis-Ghavami, Amalia S. Magaret, Gregory A. Spies, Ann Duerr, Connie L. Celum, Jorge L. Sanchez, Joseph B. Margolick, Roger Detels, M. Juliana McElrath, Lawrence Corey

Research output: Contribution to journalArticle

Abstract

Background: Adenoviruses are among the most promising vectors for the development of an HIV vaccine. The results of the phase IIB study of the adenovirus serotype 5-based Merck Trivalent HIV vaccine have raised the concern that serological immunity to adenovirus serotype 5 (Ad5) could be linked to HIV acquisition risk in high-risk individuals. We examined the association between adenovirus serostatus and the rate of incident HIV infection in populations at elevated risk of HIV acquisition. Methods: We performed a nested case-control study of Ad5 serostatus among 299 HIV-infected and 590 matched HIV-uninfected persons participating in the Multicenter AIDS Cohort Study (MACS) and in HPTN 039, a study of herpes simplex virus 2 suppression among adults in the United States, South America, and Africa. Appropriate HIV cases and controls were identified in each cohort, and Ad5-neutralizing antibody titers were compared in these two groups. Results: In MACS and HPTN 039, the relative risks of incident HIV infection among Ad5-seropositive vs. Ad5-seronegative individuals were 1.1 (95% confidence interval 0.8-1.5, P = 0.57) and 1.0 (95% confidence interval 0.4-2.3, P = 0.99), respectively. HIV-1 acquisition rates did not vary significantly by Ad5-neutralizing antibody titer. Conclusion: The presence of Ad5-neutralizing antibodies is not linked to the risk of HIV acquisition among populations at elevated risk of HIV infection.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalAIDS
Volume25
Issue number2
DOIs
StatePublished - Jan 14 2011

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Keywords

  • HIV
  • MSM
  • acquisition risk
  • adenovirus
  • serology
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Curlin, M. E., Cassis-Ghavami, F., Magaret, A. S., Spies, G. A., Duerr, A., Celum, C. L., Sanchez, J. L., Margolick, J. B., Detels, R., McElrath, M. J., & Corey, L. (2011). Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: A case-control study. AIDS, 25(2), 153-158. https://doi.org/10.1097/QAD.0b013e328342115c