Serological evidence of infections and Type 2 diabetes: The Multiethnic Study of Atherosclerosis: Original Article: Epidemiology

P. L. Lutsey, J. S. Pankow, A. G. Bertoni, Moyses Szklo, A. R. Folsom

Research output: Contribution to journalArticle

Abstract

Prospective studies have identified chronic inflammation as a risk factor for Type 2 diabetes. However, it is not known whether infection by specific pathogens or having a greater 'pathogen burden' is associated with diabetes. The aim of this study was to examine the cross-sectional relation of seropositivity to five pathogens (Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, hepatitis A virus, herpes simplex virus) and prevalent diabetes. Methods : Baseline data from a random sample of MultiEthnic Study of Atherosclerosis (MESA) participants (n = 1000; age 45-84 years) were used. Diabetes was defined by American Diabetes Association 2003 criteria, and 'pathogen burden' by the number of pathogens (0-5) for which an individual was seropositive. Logistic regression was used to test differences in diabetes prevalence by seropositivity. Linear regression was used to explore associations between pathogen seropositivity and the inflammation markers C-reactive protein, interleukin-6 and fibrinogen. Results : Diabetes prevalence was 12.7%, whereas seropositivity for C. pnuemoniae was 76%, cytomegalovirus 77%, H. pylori 45%, hepatitis A 58% and herpes simplex virus 85%. Seventy-two percent were seropositive for three or more pathogens. In crude analyses, the prevalence of diabetes was higher among those with a pathogen burden of three or more, and with seropositivity to cytomegalovirus, H. pylori, hepatitis A and herpes simplex virus. After adjustment for demographic covariates (particularly race), all associations became non-significant. Pathogen seropositivity was also not related to inflammation marker levels. Conclusions : Following demographic adjustments, no associations were observed between infection by several pathogens and diabetes status, suggesting no aetiological role for them in the occurrence of diabetes.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalDiabetic Medicine
Volume26
Issue number2
DOIs
StatePublished - Feb 2009

Fingerprint

Simplexvirus
Cytomegalovirus
Helicobacter pylori
Type 2 Diabetes Mellitus
Atherosclerosis
Epidemiology
Hepatitis A
Inflammation
Infection
Demography
Hepatitis A virus
Chlamydophila pneumoniae
C-Reactive Protein
Fibrinogen
Linear Models
Interleukin-6
Logistic Models
Prospective Studies

Keywords

  • Diabetes
  • Infection
  • Pathogen
  • Seropositivity

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Serological evidence of infections and Type 2 diabetes : The Multiethnic Study of Atherosclerosis: Original Article: Epidemiology. / Lutsey, P. L.; Pankow, J. S.; Bertoni, A. G.; Szklo, Moyses; Folsom, A. R.

In: Diabetic Medicine, Vol. 26, No. 2, 02.2009, p. 149-152.

Research output: Contribution to journalArticle

Lutsey, P. L. ; Pankow, J. S. ; Bertoni, A. G. ; Szklo, Moyses ; Folsom, A. R. / Serological evidence of infections and Type 2 diabetes : The Multiethnic Study of Atherosclerosis: Original Article: Epidemiology. In: Diabetic Medicine. 2009 ; Vol. 26, No. 2. pp. 149-152.
@article{ab05070e397b4117801ea756f8fa7802,
title = "Serological evidence of infections and Type 2 diabetes: The Multiethnic Study of Atherosclerosis: Original Article: Epidemiology",
abstract = "Prospective studies have identified chronic inflammation as a risk factor for Type 2 diabetes. However, it is not known whether infection by specific pathogens or having a greater 'pathogen burden' is associated with diabetes. The aim of this study was to examine the cross-sectional relation of seropositivity to five pathogens (Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, hepatitis A virus, herpes simplex virus) and prevalent diabetes. Methods : Baseline data from a random sample of MultiEthnic Study of Atherosclerosis (MESA) participants (n = 1000; age 45-84 years) were used. Diabetes was defined by American Diabetes Association 2003 criteria, and 'pathogen burden' by the number of pathogens (0-5) for which an individual was seropositive. Logistic regression was used to test differences in diabetes prevalence by seropositivity. Linear regression was used to explore associations between pathogen seropositivity and the inflammation markers C-reactive protein, interleukin-6 and fibrinogen. Results : Diabetes prevalence was 12.7{\%}, whereas seropositivity for C. pnuemoniae was 76{\%}, cytomegalovirus 77{\%}, H. pylori 45{\%}, hepatitis A 58{\%} and herpes simplex virus 85{\%}. Seventy-two percent were seropositive for three or more pathogens. In crude analyses, the prevalence of diabetes was higher among those with a pathogen burden of three or more, and with seropositivity to cytomegalovirus, H. pylori, hepatitis A and herpes simplex virus. After adjustment for demographic covariates (particularly race), all associations became non-significant. Pathogen seropositivity was also not related to inflammation marker levels. Conclusions : Following demographic adjustments, no associations were observed between infection by several pathogens and diabetes status, suggesting no aetiological role for them in the occurrence of diabetes.",
keywords = "Diabetes, Infection, Pathogen, Seropositivity",
author = "Lutsey, {P. L.} and Pankow, {J. S.} and Bertoni, {A. G.} and Moyses Szklo and Folsom, {A. R.}",
year = "2009",
month = "2",
doi = "10.1111/j.1464-5491.2008.02632.x",
language = "English (US)",
volume = "26",
pages = "149--152",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Serological evidence of infections and Type 2 diabetes

T2 - The Multiethnic Study of Atherosclerosis: Original Article: Epidemiology

AU - Lutsey, P. L.

AU - Pankow, J. S.

AU - Bertoni, A. G.

AU - Szklo, Moyses

AU - Folsom, A. R.

PY - 2009/2

Y1 - 2009/2

N2 - Prospective studies have identified chronic inflammation as a risk factor for Type 2 diabetes. However, it is not known whether infection by specific pathogens or having a greater 'pathogen burden' is associated with diabetes. The aim of this study was to examine the cross-sectional relation of seropositivity to five pathogens (Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, hepatitis A virus, herpes simplex virus) and prevalent diabetes. Methods : Baseline data from a random sample of MultiEthnic Study of Atherosclerosis (MESA) participants (n = 1000; age 45-84 years) were used. Diabetes was defined by American Diabetes Association 2003 criteria, and 'pathogen burden' by the number of pathogens (0-5) for which an individual was seropositive. Logistic regression was used to test differences in diabetes prevalence by seropositivity. Linear regression was used to explore associations between pathogen seropositivity and the inflammation markers C-reactive protein, interleukin-6 and fibrinogen. Results : Diabetes prevalence was 12.7%, whereas seropositivity for C. pnuemoniae was 76%, cytomegalovirus 77%, H. pylori 45%, hepatitis A 58% and herpes simplex virus 85%. Seventy-two percent were seropositive for three or more pathogens. In crude analyses, the prevalence of diabetes was higher among those with a pathogen burden of three or more, and with seropositivity to cytomegalovirus, H. pylori, hepatitis A and herpes simplex virus. After adjustment for demographic covariates (particularly race), all associations became non-significant. Pathogen seropositivity was also not related to inflammation marker levels. Conclusions : Following demographic adjustments, no associations were observed between infection by several pathogens and diabetes status, suggesting no aetiological role for them in the occurrence of diabetes.

AB - Prospective studies have identified chronic inflammation as a risk factor for Type 2 diabetes. However, it is not known whether infection by specific pathogens or having a greater 'pathogen burden' is associated with diabetes. The aim of this study was to examine the cross-sectional relation of seropositivity to five pathogens (Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, hepatitis A virus, herpes simplex virus) and prevalent diabetes. Methods : Baseline data from a random sample of MultiEthnic Study of Atherosclerosis (MESA) participants (n = 1000; age 45-84 years) were used. Diabetes was defined by American Diabetes Association 2003 criteria, and 'pathogen burden' by the number of pathogens (0-5) for which an individual was seropositive. Logistic regression was used to test differences in diabetes prevalence by seropositivity. Linear regression was used to explore associations between pathogen seropositivity and the inflammation markers C-reactive protein, interleukin-6 and fibrinogen. Results : Diabetes prevalence was 12.7%, whereas seropositivity for C. pnuemoniae was 76%, cytomegalovirus 77%, H. pylori 45%, hepatitis A 58% and herpes simplex virus 85%. Seventy-two percent were seropositive for three or more pathogens. In crude analyses, the prevalence of diabetes was higher among those with a pathogen burden of three or more, and with seropositivity to cytomegalovirus, H. pylori, hepatitis A and herpes simplex virus. After adjustment for demographic covariates (particularly race), all associations became non-significant. Pathogen seropositivity was also not related to inflammation marker levels. Conclusions : Following demographic adjustments, no associations were observed between infection by several pathogens and diabetes status, suggesting no aetiological role for them in the occurrence of diabetes.

KW - Diabetes

KW - Infection

KW - Pathogen

KW - Seropositivity

UR - http://www.scopus.com/inward/record.url?scp=60049100702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60049100702&partnerID=8YFLogxK

U2 - 10.1111/j.1464-5491.2008.02632.x

DO - 10.1111/j.1464-5491.2008.02632.x

M3 - Article

C2 - 19236617

AN - SCOPUS:60049100702

VL - 26

SP - 149

EP - 152

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 2

ER -