Sera from 4 groups of donors were tested for the presence of simian virus 40 (SV40)-reacting antibodies. Neutralizing antibodies were found in about 20% of the sera of Maryland children born between 1955 and 1957. This group had a high risk of having received SV40- contaminated Salk poliomyelitis vaccine. SV40-neutra!izing antibodies were also found in 9 (3.2%) sera of Maryland children born during or after 1964. Since 1961, vaccines were required to be free of SV40; thus it is unlikely that these children received SV40 in contaminated vaccines. Furthermore, SV40-reacting antibodies were detected in 4 (2%) sera from collections made in 1951 and 1954, before monkey kidney vaccines came into general use. The validity of the results from neutralization tests was confirmed by indirect immunofluorescence and radioisotope precipitation tests. The occurrence of SV40-reacting antibodies in sera of young Maryland children and in sera collected in the early 1950's strongly suggests the existence of an SV40-related infection of man. —J Nat Cancer Inst 48: 557-561, 1972.
ASJC Scopus subject areas
- Cancer Research