Seroepidemiology of strongyloidiasis in the Peruvian Amazon

Pablo P. Yori, Margaret Kosek, Robert H. Gilman, Julianna Cordova, Caryn Bern, Cesar Banda Chavez, Maribel Paredes Olortegui, Carmen Montalvan, Graciela Meza Sanchez, Bevelle Worthen, James Worthen, Fay Leung, Carlos Vidal Ore

Research output: Contribution to journalArticle

Abstract

A stool and serosurvey for Strongyloides stercoralis was conducted in a community in the Peruvian Amazon region. Strongyloidiasis stercoralis was identified in the stool of 69 (8.7%) of 792 participants. Six hundred nine sera were tested using by an enzyme-linked immunosorbent assay (ELISA), which had a sensitivity of 92% and a specificity of 94%; 442 (72%) were positive. In multivariable logistic regression models, having S. stercoralis in stool was associated with hookworm in the same specimen (odds ratio [OR] = 4.44, 95% confidence interval [CI] = 2.02-9.79), occasionally or never wearing shoes (OR = 1.89, 95% CI = 1.10-3.27), and increasing age (OR = 1.012 for each one-year increase, 95% CI = 1.00-1.03). Similarly, occasionally or never wearing shoes (OR = 1.54, 95% CI = 1.01-2.37) and increasing age (OR = 1.04 for each one-year increase, 95% CI = 1.02-1.06) were associated with an increased risk of a positive S. stercoralis ELISA result. The ELISA had a negative predictive value of 98% and is an excellent screening test for strongyloidiasis.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume74
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Yori, P. P., Kosek, M., Gilman, R. H., Cordova, J., Bern, C., Chavez, C. B., Olortegui, M. P., Montalvan, C., Sanchez, G. M., Worthen, B., Worthen, J., Leung, F., & Ore, C. V. (2006). Seroepidemiology of strongyloidiasis in the Peruvian Amazon. American Journal of Tropical Medicine and Hygiene, 74(1), 97-102. https://doi.org/10.4269/ajtmh.2006.74.97