SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues

Research output: Contribution to journalShort survey

Abstract

In this issue of Molecular Cell, Bonfiglio et al. (2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones. Here, mechanisms and implications of this unexpected, O-linked ADP-ribosylation are speculated on.

Original languageEnglish (US)
Pages (from-to)777-778
Number of pages2
JournalMolecular Cell
Volume65
Issue number5
DOIs
StatePublished - Mar 2 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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