Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration

Paul M. Kim; Hiroyuki Aizawa; Peter S. Kim; Alex S. Huang; Sasrutha R. Wickramasinghe; Amir H. Kashani; Roxanne K. Barrow; Richard L. Huganir; Anirvan Ghosh; Solomon H. Snyder

doi:10.1073/pnas.0409723102

Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration

Paul M. Kim, Hiroyuki Aizawa, Peter S. Kim, Alex S. Huang, Sasrutha R. Wickramasinghe, Amir H. Kashani, Roxanne K. Barrow, Richard L. Huganir, Anirvan Ghosh, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR. GRIP physiologically binds SR, augmenting SR activity and D-serine release. GRIP infection of neonatal mouse cerebellum in vivo enhances granule cell migration. Selective degradation of D-serine by D-amino acid oxidase and pharmacologic inhibition of SR impede migration, whereas D-serine activates the process. Thus, in neuronal migration, glutamate stimulates Bergmann glia to form and release D-serine, which, together with glutamate, activates NMDA receptors on granule neurons, chemokinetically enhancing migration.

Original language	English (US)
Pages (from-to)	2105-2110
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	6
DOIs	https://doi.org/10.1073/pnas.0409723102
State	Published - Feb 8 2005

Keywords

D-serine
α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.0409723102

Fingerprint Dive into the research topics of 'Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration'. Together they form a unique fingerprint.

Cite this

Kim, P. M., Aizawa, H., Kim, P. S., Huang, A. S., Wickramasinghe, S. R., Kashani, A. H., Barrow, R. K., Huganir, R. L., Ghosh, A., & Snyder, S. H. (2005). Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proceedings of the National Academy of Sciences of the United States of America, 102(6), 2105-2110. https://doi.org/10.1073/pnas.0409723102

Serine racemase : Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. / Kim, Paul M.; Aizawa, Hiroyuki; Kim, Peter S.; Huang, Alex S.; Wickramasinghe, Sasrutha R.; Kashani, Amir H.; Barrow, Roxanne K.; Huganir, Richard L.; Ghosh, Anirvan; Snyder, Solomon H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 6, 08.02.2005, p. 2105-2110.

Research output: Contribution to journal › Article › peer-review

Kim, PM, Aizawa, H, Kim, PS, Huang, AS, Wickramasinghe, SR, Kashani, AH, Barrow, RK , Huganir, RL, Ghosh, A & Snyder, SH 2005, 'Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 6, pp. 2105-2110. https://doi.org/10.1073/pnas.0409723102

Kim, Paul M. ; Aizawa, Hiroyuki ; Kim, Peter S. ; Huang, Alex S. ; Wickramasinghe, Sasrutha R. ; Kashani, Amir H. ; Barrow, Roxanne K. ; Huganir, Richard L. ; Ghosh, Anirvan ; Snyder, Solomon H. / Serine racemase : Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 6. pp. 2105-2110.

@article{7f4197d65c1c473f880e3631e93be183,

title = "Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration",

abstract = "Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR. GRIP physiologically binds SR, augmenting SR activity and D-serine release. GRIP infection of neonatal mouse cerebellum in vivo enhances granule cell migration. Selective degradation of D-serine by D-amino acid oxidase and pharmacologic inhibition of SR impede migration, whereas D-serine activates the process. Thus, in neuronal migration, glutamate stimulates Bergmann glia to form and release D-serine, which, together with glutamate, activates NMDA receptors on granule neurons, chemokinetically enhancing migration.",

keywords = "D-serine, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor",

author = "Kim, {Paul M.} and Hiroyuki Aizawa and Kim, {Peter S.} and Huang, {Alex S.} and Wickramasinghe, {Sasrutha R.} and Kashani, {Amir H.} and Barrow, {Roxanne K.} and Huganir, {Richard L.} and Anirvan Ghosh and Snyder, {Solomon H.}",

year = "2005",

month = feb,

day = "8",

doi = "10.1073/pnas.0409723102",

language = "English (US)",

volume = "102",

pages = "2105--2110",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "6",

}

TY - JOUR

T1 - Serine racemase

T2 - Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration

AU - Kim, Paul M.

AU - Aizawa, Hiroyuki

AU - Kim, Peter S.

AU - Huang, Alex S.

AU - Wickramasinghe, Sasrutha R.

AU - Kashani, Amir H.

AU - Barrow, Roxanne K.

AU - Huganir, Richard L.

AU - Ghosh, Anirvan

AU - Snyder, Solomon H.

PY - 2005/2/8

Y1 - 2005/2/8

N2 - Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR. GRIP physiologically binds SR, augmenting SR activity and D-serine release. GRIP infection of neonatal mouse cerebellum in vivo enhances granule cell migration. Selective degradation of D-serine by D-amino acid oxidase and pharmacologic inhibition of SR impede migration, whereas D-serine activates the process. Thus, in neuronal migration, glutamate stimulates Bergmann glia to form and release D-serine, which, together with glutamate, activates NMDA receptors on granule neurons, chemokinetically enhancing migration.

AB - Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR. GRIP physiologically binds SR, augmenting SR activity and D-serine release. GRIP infection of neonatal mouse cerebellum in vivo enhances granule cell migration. Selective degradation of D-serine by D-amino acid oxidase and pharmacologic inhibition of SR impede migration, whereas D-serine activates the process. Thus, in neuronal migration, glutamate stimulates Bergmann glia to form and release D-serine, which, together with glutamate, activates NMDA receptors on granule neurons, chemokinetically enhancing migration.

KW - D-serine

KW - α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor

UR - http://www.scopus.com/inward/record.url?scp=13844306349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844306349&partnerID=8YFLogxK

U2 - 10.1073/pnas.0409723102

DO - 10.1073/pnas.0409723102

M3 - Article

C2 - 15684087

AN - SCOPUS:13844306349

VL - 102

SP - 2105

EP - 2110

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 6

ER -

Serine racemase: Activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this