Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development

Ashten N. Omstead; Juliann E. Kosovec; Daisuke Matsui; Samantha A. Martin; Matthew A. Smith; D. Aaron Guel; Jenna Kolano; Yoshihiro Komatsu; Fahim Habib; Christopher Lai; Kevi Christopher; Ronan J. Kelly; Ali H. Zaidi; Blair A. Jobe

doi:10.1080/07357907.2018.1499029

Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development

Ashten N. Omstead, Juliann E. Kosovec, Daisuke Matsui, Samantha A. Martin, Matthew A. Smith, D. Aaron Guel, Jenna Kolano, Yoshihiro Komatsu, Fahim Habib, Christopher Lai, Kevi Christopher, Ronan J. Kelly, Ali H. Zaidi, Blair A. Jobe

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2 Scopus citations

Abstract

A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett’s with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.

Original language	English (US)
Pages (from-to)	363-370
Number of pages	8
Journal	Cancer Investigation
Volume	36
Issue number	7
DOIs	https://doi.org/10.1080/07357907.2018.1499029
State	Published - Aug 9 2018
Externally published	Yes

Keywords

Barrett’s Esophagus
Disease Progression
Dysplasia
Endoscopic Evaluation
Endoscopy
Esophageal Adenocarcinoma
Rat Model

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1080/07357907.2018.1499029

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Omstead, A. N., Kosovec, J. E., Matsui, D., Martin, S. A., Smith, M. A., Aaron Guel, D., Kolano, J., Komatsu, Y., Habib, F., Lai, C., Christopher, K., Kelly, R. J., Zaidi, A. H., & Jobe, B. A. (2018). Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development. Cancer Investigation, 36(7), 363-370. https://doi.org/10.1080/07357907.2018.1499029

Omstead, AN, Kosovec, JE, Matsui, D, Martin, SA, Smith, MA, Aaron Guel, D, Kolano, J, Komatsu, Y, Habib, F, Lai, C, Christopher, K, Kelly, RJ, Zaidi, AH & Jobe, BA 2018, 'Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development', Cancer Investigation, vol. 36, no. 7, pp. 363-370. https://doi.org/10.1080/07357907.2018.1499029

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title = "Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development",

abstract = "A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett{\textquoteright}s with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.",

keywords = "Barrett{\textquoteright}s Esophagus, Disease Progression, Dysplasia, Endoscopic Evaluation, Endoscopy, Esophageal Adenocarcinoma, Rat Model",

author = "Omstead, {Ashten N.} and Kosovec, {Juliann E.} and Daisuke Matsui and Martin, {Samantha A.} and Smith, {Matthew A.} and {Aaron Guel}, D. and Jenna Kolano and Yoshihiro Komatsu and Fahim Habib and Christopher Lai and Kevi Christopher and Kelly, {Ronan J.} and Zaidi, {Ali H.} and Jobe, {Blair A.}",

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year = "2018",

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doi = "10.1080/07357907.2018.1499029",

language = "English (US)",

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AU - Aaron Guel, D.

AU - Kolano, Jenna

AU - Komatsu, Yoshihiro

AU - Habib, Fahim

AU - Lai, Christopher

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AB - A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett’s with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.

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KW - Endoscopic Evaluation

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KW - Esophageal Adenocarcinoma

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Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development

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