Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development

Ashten N. Omstead, Juliann E. Kosovec, Daisuke Matsui, Samantha A. Martin, Matthew A. Smith, D. Aaron Guel, Jenna Kolano, Yoshihiro Komatsu, Fahim Habib, Christopher Lai, Kevi Christopher, Ronan Joseph Kelly, Ali H. Zaidi, Blair A. Jobe

Research output: Contribution to journalArticle

Abstract

A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett’s with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.

Original languageEnglish (US)
JournalCancer Investigation
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Barrett’s Esophagus
  • Disease Progression
  • Dysplasia
  • Endoscopic Evaluation
  • Endoscopy
  • Esophageal Adenocarcinoma
  • Rat Model

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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