Serial changes of soluble endothelin-1 levels during myocardial ischaemia-reperfusion. Effects of magnesium, diltiazem and a novel MAC-1 inhibitor

Victor L. Serebruany, Matthew L. Schlossberg, Lisa R. Edenbaum, William R. Herzog, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

The key role of endothelin-1 (ET-1) has been recognised in patients with ischaemic heart disease. However, the serial changes of ET-1 during both brief and prolonged ischaemia-reperfusion are poorly known. Serial changes of plasma ET-1 were measured during myocardial stunning (MS) and acute myocardial infarction (AMI). The effects of magnesium (Mg), diltiazem and a MAC-1 inhibitor on the plasma ET-1 were elucidated. Forty-nine swine underwent brief (8 min) or prolonged (50 min) coronary artery occlusion followed by reperfusion. ET-1 plasma concentration was measured by ELISA at prespecified time points. The occlusion was associated with a decline of ET-1 followed by a significant increase during the reperfusion. Mg as well as diltiazem similarly affected the plasma ET-1 by reducing ET-1 release during the first hour of the reperfusion period. MAC-1 inhibition was also associated with decreases of ET-1. Ability of Mg, diltiazem and leumedins to decrease the ET-1 plasma level may have direct clinical implications for the use of these agents in patients with coronary artery disease.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalPharmacological Research
Volume38
Issue number3
DOIs
StatePublished - Sep 1998

Keywords

  • Acute myocardial infarction
  • Animal model
  • Diltiazem
  • Endothelin-1
  • MAC-1
  • Magnesium
  • Myocardial stunning

ASJC Scopus subject areas

  • Pharmacology

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