Serial changes in plasma brain natriuretic peptide concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction

Atsushi Hirayama, H. Kusuoka, H. Yamamoto, Y. Sakata, M. Asakura, Y. Higuchi, H. Mizuno, K. Kashiwase, Y. Ueda, Y. Okuyama, M. Hori, K. Kodama

Research output: Contribution to journalArticle

Abstract

Objectives: To clarify the role of infarct and non-infarct sites on left ventricular (LV) remodelling after myocardial infarction by measuring brain natriuretic peptide (BNP) from each site. Methods and results: BNP from the aorta and the anterior interventricular vein (AIV) was measured in 45 patients with first anterior myocardial infarction at one, six, and 18 months. The LV was significantly dilated (> 10 ml/m2 of end diastolic volume from one to 18 months) in 20 patients (remodelling (R) group) but not in 25 others (non-remodelling (NR) group). Patient characteristics and LV functions did not differ significantly at one month but plasma BNP concentration was higher in group R than in group NR (336 (288) v 116 (106) pg/ml, p <0.01), predicting the degree of LV dilatation. The difference in BNP concentration between the aortic root and AIV (ΔBNP), reflecting BNP secreted from the infarct site, did not differ at one month. In both groups BNP and ΔBNP significantly decreased from one to six months (p <0.05) and decreased from six months to 18 months, but the change was not significant. BNP and ΔBNP were significantly higher in group R than in group NR after six months, when LV dilatation was not evident in both groups. Conclusion: Enhanced BNP secretion at one month in the non-infarct and infarct ventricular sites predicts subsequent LV dilatation (that is, remodelling). The slower process of LV remodelling decreased BNP secretion at both sites. Thus, BNP concentration should be useful for monitoring ventricular remodelling after infarction.

Original languageEnglish (US)
Pages (from-to)1573-1577
Number of pages5
JournalHeart
Volume91
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Ventricular Remodeling
Brain Natriuretic Peptide
Myocardial Infarction
Dilatation
Veins
Left Ventricular Function
Infarction
Aorta

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Serial changes in plasma brain natriuretic peptide concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction. / Hirayama, Atsushi; Kusuoka, H.; Yamamoto, H.; Sakata, Y.; Asakura, M.; Higuchi, Y.; Mizuno, H.; Kashiwase, K.; Ueda, Y.; Okuyama, Y.; Hori, M.; Kodama, K.

In: Heart, Vol. 91, No. 12, 12.2005, p. 1573-1577.

Research output: Contribution to journalArticle

Hirayama, A, Kusuoka, H, Yamamoto, H, Sakata, Y, Asakura, M, Higuchi, Y, Mizuno, H, Kashiwase, K, Ueda, Y, Okuyama, Y, Hori, M & Kodama, K 2005, 'Serial changes in plasma brain natriuretic peptide concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction', Heart, vol. 91, no. 12, pp. 1573-1577. https://doi.org/10.1136/hrt.2004.049635
Hirayama, Atsushi ; Kusuoka, H. ; Yamamoto, H. ; Sakata, Y. ; Asakura, M. ; Higuchi, Y. ; Mizuno, H. ; Kashiwase, K. ; Ueda, Y. ; Okuyama, Y. ; Hori, M. ; Kodama, K. / Serial changes in plasma brain natriuretic peptide concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction. In: Heart. 2005 ; Vol. 91, No. 12. pp. 1573-1577.
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T1 - Serial changes in plasma brain natriuretic peptide concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction

AU - Hirayama, Atsushi

AU - Kusuoka, H.

AU - Yamamoto, H.

AU - Sakata, Y.

AU - Asakura, M.

AU - Higuchi, Y.

AU - Mizuno, H.

AU - Kashiwase, K.

AU - Ueda, Y.

AU - Okuyama, Y.

AU - Hori, M.

AU - Kodama, K.

PY - 2005/12

Y1 - 2005/12

N2 - Objectives: To clarify the role of infarct and non-infarct sites on left ventricular (LV) remodelling after myocardial infarction by measuring brain natriuretic peptide (BNP) from each site. Methods and results: BNP from the aorta and the anterior interventricular vein (AIV) was measured in 45 patients with first anterior myocardial infarction at one, six, and 18 months. The LV was significantly dilated (> 10 ml/m2 of end diastolic volume from one to 18 months) in 20 patients (remodelling (R) group) but not in 25 others (non-remodelling (NR) group). Patient characteristics and LV functions did not differ significantly at one month but plasma BNP concentration was higher in group R than in group NR (336 (288) v 116 (106) pg/ml, p <0.01), predicting the degree of LV dilatation. The difference in BNP concentration between the aortic root and AIV (ΔBNP), reflecting BNP secreted from the infarct site, did not differ at one month. In both groups BNP and ΔBNP significantly decreased from one to six months (p <0.05) and decreased from six months to 18 months, but the change was not significant. BNP and ΔBNP were significantly higher in group R than in group NR after six months, when LV dilatation was not evident in both groups. Conclusion: Enhanced BNP secretion at one month in the non-infarct and infarct ventricular sites predicts subsequent LV dilatation (that is, remodelling). The slower process of LV remodelling decreased BNP secretion at both sites. Thus, BNP concentration should be useful for monitoring ventricular remodelling after infarction.

AB - Objectives: To clarify the role of infarct and non-infarct sites on left ventricular (LV) remodelling after myocardial infarction by measuring brain natriuretic peptide (BNP) from each site. Methods and results: BNP from the aorta and the anterior interventricular vein (AIV) was measured in 45 patients with first anterior myocardial infarction at one, six, and 18 months. The LV was significantly dilated (> 10 ml/m2 of end diastolic volume from one to 18 months) in 20 patients (remodelling (R) group) but not in 25 others (non-remodelling (NR) group). Patient characteristics and LV functions did not differ significantly at one month but plasma BNP concentration was higher in group R than in group NR (336 (288) v 116 (106) pg/ml, p <0.01), predicting the degree of LV dilatation. The difference in BNP concentration between the aortic root and AIV (ΔBNP), reflecting BNP secreted from the infarct site, did not differ at one month. In both groups BNP and ΔBNP significantly decreased from one to six months (p <0.05) and decreased from six months to 18 months, but the change was not significant. BNP and ΔBNP were significantly higher in group R than in group NR after six months, when LV dilatation was not evident in both groups. Conclusion: Enhanced BNP secretion at one month in the non-infarct and infarct ventricular sites predicts subsequent LV dilatation (that is, remodelling). The slower process of LV remodelling decreased BNP secretion at both sites. Thus, BNP concentration should be useful for monitoring ventricular remodelling after infarction.

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