Abstract
Objective: To assess longitudinally the severity of diffuse axonal injury in the corpus callosum in patients with moderate traumatic brain injury (TBI) through quantitative diffusion tensor imaging and to correlate these changes with neuropsychometric tests (NPT) at 6 and 24 months after injury. Design: Prospective longitudinal study. Participants: Sixteen patients with TBI and 17 age/sex-matched healthy controls. Methods: Patients underwent magnetic resonance imaging at 3 time points: within 2 weeks (range = 5-14 days), 6 months, and 24 months after injury. NPT could be performed only at 6 and 24 months. Results: In patients with TBI, a significant increase in fractional anisotropy (FA) values in genu as well as an insignificant decrease in radial diffusivity (RD) and mean diffusivity values in genu and splenium were observed over time, respectively. FA, RD, and mean diffusivity values continued to be abnormal in patients compared with controls at the end of 2 years. Although some NPT scores improved over time in these patients, these were still significantly impaired compared with controls. Conclusions: FA and RD indices appear to be surrogate markers of microstructural alterations in patients over time and correlate significantly with some of the NPT scores. The recovery in these indices associated with recovery in neurocognitive deficits suggests that these indices may be used as an objective marker for residual injury in these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-42 |
| Number of pages | 12 |
| Journal | Journal of Head Trauma Rehabilitation |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2010 |
| Externally published | Yes |
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Keywords
- Corpus callosum
- Diffuse axonal injury
- Diffusion tensor imaging
- Fractional anisotropy
- Neuropsychological test
- Radial diffusivity
- Traumatic brain injury
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation
- Clinical Neurology
Cite this
Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests : A 2-Year follow-up study. / Kumar, Raj; Saksena, Sona; Husain, Mazhar; Srivastava, Arti; Rathore, Ram K.S.; Agarwal, Shruti; Gupta, Rakesh K.
In: Journal of Head Trauma Rehabilitation, Vol. 25, No. 1, 01.01.2010, p. 31-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests
T2 - A 2-Year follow-up study
AU - Kumar, Raj
AU - Saksena, Sona
AU - Husain, Mazhar
AU - Srivastava, Arti
AU - Rathore, Ram K.S.
AU - Agarwal, Shruti
AU - Gupta, Rakesh K.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Objective: To assess longitudinally the severity of diffuse axonal injury in the corpus callosum in patients with moderate traumatic brain injury (TBI) through quantitative diffusion tensor imaging and to correlate these changes with neuropsychometric tests (NPT) at 6 and 24 months after injury. Design: Prospective longitudinal study. Participants: Sixteen patients with TBI and 17 age/sex-matched healthy controls. Methods: Patients underwent magnetic resonance imaging at 3 time points: within 2 weeks (range = 5-14 days), 6 months, and 24 months after injury. NPT could be performed only at 6 and 24 months. Results: In patients with TBI, a significant increase in fractional anisotropy (FA) values in genu as well as an insignificant decrease in radial diffusivity (RD) and mean diffusivity values in genu and splenium were observed over time, respectively. FA, RD, and mean diffusivity values continued to be abnormal in patients compared with controls at the end of 2 years. Although some NPT scores improved over time in these patients, these were still significantly impaired compared with controls. Conclusions: FA and RD indices appear to be surrogate markers of microstructural alterations in patients over time and correlate significantly with some of the NPT scores. The recovery in these indices associated with recovery in neurocognitive deficits suggests that these indices may be used as an objective marker for residual injury in these patients.
AB - Objective: To assess longitudinally the severity of diffuse axonal injury in the corpus callosum in patients with moderate traumatic brain injury (TBI) through quantitative diffusion tensor imaging and to correlate these changes with neuropsychometric tests (NPT) at 6 and 24 months after injury. Design: Prospective longitudinal study. Participants: Sixteen patients with TBI and 17 age/sex-matched healthy controls. Methods: Patients underwent magnetic resonance imaging at 3 time points: within 2 weeks (range = 5-14 days), 6 months, and 24 months after injury. NPT could be performed only at 6 and 24 months. Results: In patients with TBI, a significant increase in fractional anisotropy (FA) values in genu as well as an insignificant decrease in radial diffusivity (RD) and mean diffusivity values in genu and splenium were observed over time, respectively. FA, RD, and mean diffusivity values continued to be abnormal in patients compared with controls at the end of 2 years. Although some NPT scores improved over time in these patients, these were still significantly impaired compared with controls. Conclusions: FA and RD indices appear to be surrogate markers of microstructural alterations in patients over time and correlate significantly with some of the NPT scores. The recovery in these indices associated with recovery in neurocognitive deficits suggests that these indices may be used as an objective marker for residual injury in these patients.
KW - Corpus callosum
KW - Diffuse axonal injury
KW - Diffusion tensor imaging
KW - Fractional anisotropy
KW - Neuropsychological test
KW - Radial diffusivity
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=75649135340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75649135340&partnerID=8YFLogxK
U2 - 10.1097/HTR.0b013e3181bff331
DO - 10.1097/HTR.0b013e3181bff331
M3 - Article
C2 - 20051898
AN - SCOPUS:75649135340
VL - 25
SP - 31
EP - 42
JO - Journal of Head Trauma Rehabilitation
JF - Journal of Head Trauma Rehabilitation
SN - 0885-9701
IS - 1
ER -