Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests: A 2-Year follow-up study

Raj Kumar, Sona Saksena, Mazhar Husain, Arti Srivastava, Ram K.S. Rathore, Shruti Agarwal, Rakesh K. Gupta

Research output: Contribution to journalArticle

Abstract

Objective: To assess longitudinally the severity of diffuse axonal injury in the corpus callosum in patients with moderate traumatic brain injury (TBI) through quantitative diffusion tensor imaging and to correlate these changes with neuropsychometric tests (NPT) at 6 and 24 months after injury. Design: Prospective longitudinal study. Participants: Sixteen patients with TBI and 17 age/sex-matched healthy controls. Methods: Patients underwent magnetic resonance imaging at 3 time points: within 2 weeks (range = 5-14 days), 6 months, and 24 months after injury. NPT could be performed only at 6 and 24 months. Results: In patients with TBI, a significant increase in fractional anisotropy (FA) values in genu as well as an insignificant decrease in radial diffusivity (RD) and mean diffusivity values in genu and splenium were observed over time, respectively. FA, RD, and mean diffusivity values continued to be abnormal in patients compared with controls at the end of 2 years. Although some NPT scores improved over time in these patients, these were still significantly impaired compared with controls. Conclusions: FA and RD indices appear to be surrogate markers of microstructural alterations in patients over time and correlate significantly with some of the NPT scores. The recovery in these indices associated with recovery in neurocognitive deficits suggests that these indices may be used as an objective marker for residual injury in these patients.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalJournal of Head Trauma Rehabilitation
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Diffusion Tensor Imaging
Corpus Callosum
varespladib methyl
Anisotropy
Wounds and Injuries
Diffuse Axonal Injury
Traumatic Brain Injury
Longitudinal Studies
Biomarkers
Magnetic Resonance Imaging
Prospective Studies

Keywords

  • Corpus callosum
  • Diffuse axonal injury
  • Diffusion tensor imaging
  • Fractional anisotropy
  • Neuropsychological test
  • Radial diffusivity
  • Traumatic brain injury

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology

Cite this

Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests : A 2-Year follow-up study. / Kumar, Raj; Saksena, Sona; Husain, Mazhar; Srivastava, Arti; Rathore, Ram K.S.; Agarwal, Shruti; Gupta, Rakesh K.

In: Journal of Head Trauma Rehabilitation, Vol. 25, No. 1, 01.01.2010, p. 31-42.

Research output: Contribution to journalArticle

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