Serial analysis of gene expression (SAGE): Advances, analysis and applications to pigment cell research

Research output: Contribution to journalReview article

Abstract

As cells progress from normal to diseased states, they may undergo a series of gene expression changes. Advances in molecular biology allow us to examine a host of these changes at once, in a high throughput fashion. Serial analysis of gene expression (SAGE) allows for the expression profiling of the complete transcriptome of a given cell, and has the potential for identifying novel genes as well as those in low abundance. In this review, we will outline the technique, how one analyzes the massive amounts of data generated, and describe pigment cell libraries currently in the making.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalPigment Cell Research
Volume16
Issue number3
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Keywords

  • Gene expression profiling
  • Melanoma
  • Pigment
  • SAGE

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Developmental Biology
  • Clinical Biochemistry
  • Cell Biology

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