Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder

Y. Sun, L. Zhang, N. L. Johnston, E. F. Torrey, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Background: Bipolar disorder is a serious brain disease affecting more than a million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. Aim: To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. Method: Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained post-mortem from individuals with bipolar disorder compared with other psychiatric and control conditions. Results: Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-κB transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. Conclusion: The SAGE technique offers promise for the characterisation of complex human brain diseases. Declaration of interest: This research was supported by the Theodore and Vada Stanley Foundation.

Original languageEnglish (US)
JournalBritish Journal of Psychiatry
Volume178
Issue numberSUPPL. 141
StatePublished - 2001

Fingerprint

Frontal Lobe
Bipolar Disorder
RNA
Gene Expression
Brain Diseases
Serotonin Plasma Membrane Transport Proteins
Brain
Depressive Disorder
Reverse Transcriptase Polymerase Chain Reaction
Psychiatry
Epidemiologic Studies
Schizophrenia
Transcription Factors
Research
Proteins

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder. / Sun, Y.; Zhang, L.; Johnston, N. L.; Torrey, E. F.; Yolken, Robert H.

In: British Journal of Psychiatry, Vol. 178, No. SUPPL. 141, 2001.

Research output: Contribution to journalArticle

Sun, Y. ; Zhang, L. ; Johnston, N. L. ; Torrey, E. F. ; Yolken, Robert H. / Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder. In: British Journal of Psychiatry. 2001 ; Vol. 178, No. SUPPL. 141.
@article{c4e980f312ba471f8ed3c9fe97e85d0d,
title = "Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder",
abstract = "Background: Bipolar disorder is a serious brain disease affecting more than a million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. Aim: To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. Method: Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained post-mortem from individuals with bipolar disorder compared with other psychiatric and control conditions. Results: Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-κB transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. Conclusion: The SAGE technique offers promise for the characterisation of complex human brain diseases. Declaration of interest: This research was supported by the Theodore and Vada Stanley Foundation.",
author = "Y. Sun and L. Zhang and Johnston, {N. L.} and Torrey, {E. F.} and Yolken, {Robert H}",
year = "2001",
language = "English (US)",
volume = "178",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "SUPPL. 141",

}

TY - JOUR

T1 - Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder

AU - Sun, Y.

AU - Zhang, L.

AU - Johnston, N. L.

AU - Torrey, E. F.

AU - Yolken, Robert H

PY - 2001

Y1 - 2001

N2 - Background: Bipolar disorder is a serious brain disease affecting more than a million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. Aim: To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. Method: Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained post-mortem from individuals with bipolar disorder compared with other psychiatric and control conditions. Results: Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-κB transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. Conclusion: The SAGE technique offers promise for the characterisation of complex human brain diseases. Declaration of interest: This research was supported by the Theodore and Vada Stanley Foundation.

AB - Background: Bipolar disorder is a serious brain disease affecting more than a million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. Aim: To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. Method: Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained post-mortem from individuals with bipolar disorder compared with other psychiatric and control conditions. Results: Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-κB transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. Conclusion: The SAGE technique offers promise for the characterisation of complex human brain diseases. Declaration of interest: This research was supported by the Theodore and Vada Stanley Foundation.

UR - http://www.scopus.com/inward/record.url?scp=0034982912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034982912&partnerID=8YFLogxK

M3 - Article

C2 - 11450174

AN - SCOPUS:0034982912

VL - 178

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - SUPPL. 141

ER -