Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen

Sangeeta Ray Banerjee, Mrudula Pullambhatla, Youngjoo Byun, Sridhar Nimmagadda, Catherine A. Foss, Gilbert Green, James J. Fox, Shawn E. Lupold, Ronnie C. Mease, Martin G. Pomper

Research output: Contribution to journalArticle

Abstract

One reagent for two techniques: Compound [ 111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate-specific membrane antigen. Because the same subject can be dual-imaged after one injection of the agent, these findings support rapid clinical translation.

Original languageEnglish (US)
Pages (from-to)9167-9170
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number39
DOIs
StatePublished - Sep 19 2011

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Keywords

  • fluorescent probes
  • imaging agents
  • prostate cancer
  • prostate-specific membrane antigen
  • radiochemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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