Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen

Sangeeta Ray, Mrudula Pullambhatla, Youngjoo Byun, Sridhar Nimmagadda, Catherine Foss, Gilbert Green, James J. Fox, Shawn Lupold, Ronnie Mease, Martin Gilbert Pomper

Research output: Contribution to journalArticle

Abstract

One reagent for two techniques: Compound [ 111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate-specific membrane antigen. Because the same subject can be dual-imaged after one injection of the agent, these findings support rapid clinical translation.

Original languageEnglish (US)
Pages (from-to)9167-9170
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number39
DOIs
StatePublished - Sep 19 2011

Fingerprint

Antigens
Radioisotopes
Membranes
Imaging techniques
human glutamate carboxypeptidase II

Keywords

  • fluorescent probes
  • imaging agents
  • prostate cancer
  • prostate-specific membrane antigen
  • radiochemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

@article{6f061c6e8bbe42aaa0990937c4f8d612,
title = "Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen",
abstract = "One reagent for two techniques: Compound [ 111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate-specific membrane antigen. Because the same subject can be dual-imaged after one injection of the agent, these findings support rapid clinical translation.",
keywords = "fluorescent probes, imaging agents, prostate cancer, prostate-specific membrane antigen, radiochemistry",
author = "Sangeeta Ray and Mrudula Pullambhatla and Youngjoo Byun and Sridhar Nimmagadda and Catherine Foss and Gilbert Green and Fox, {James J.} and Shawn Lupold and Ronnie Mease and Pomper, {Martin Gilbert}",
year = "2011",
month = "9",
day = "19",
doi = "10.1002/anie.201102872",
language = "English (US)",
volume = "50",
pages = "9167--9170",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "39",

}

TY - JOUR

T1 - Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen

AU - Ray, Sangeeta

AU - Pullambhatla, Mrudula

AU - Byun, Youngjoo

AU - Nimmagadda, Sridhar

AU - Foss, Catherine

AU - Green, Gilbert

AU - Fox, James J.

AU - Lupold, Shawn

AU - Mease, Ronnie

AU - Pomper, Martin Gilbert

PY - 2011/9/19

Y1 - 2011/9/19

N2 - One reagent for two techniques: Compound [ 111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate-specific membrane antigen. Because the same subject can be dual-imaged after one injection of the agent, these findings support rapid clinical translation.

AB - One reagent for two techniques: Compound [ 111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate-specific membrane antigen. Because the same subject can be dual-imaged after one injection of the agent, these findings support rapid clinical translation.

KW - fluorescent probes

KW - imaging agents

KW - prostate cancer

KW - prostate-specific membrane antigen

KW - radiochemistry

UR - http://www.scopus.com/inward/record.url?scp=80052845758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052845758&partnerID=8YFLogxK

U2 - 10.1002/anie.201102872

DO - 10.1002/anie.201102872

M3 - Article

VL - 50

SP - 9167

EP - 9170

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 39

ER -