Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex

Bin Jiang, Mario Treviño, Alfredo Kirkwood

Research output: Contribution to journalArticle

Abstract

Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.

Original languageEnglish (US)
Pages (from-to)9648-9652
Number of pages5
JournalJournal of Neuroscience
Volume27
Issue number36
DOIs
StatePublished - Sep 5 2007

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Keywords

  • Critical period
  • LTD
  • LTP
  • Layer II/III
  • Layer IV
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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