Sequential computed tomographic imaging of a transplantable rabbit brain tumor

A. J. Kumar, S. Hassenbusch, A. E. Rosenbaum, T. J. Beck, R. Hadfield, H. S. Ahn, J. Anderson

Research output: Contribution to journalArticle

Abstract

The accuracy of CT imaging in evaluating VX-2 tumor growth in the rabbit brain was assessed. CT scanning was performed in 5 outbred New Zealand white male rabbits before and at 4, 7, 9 and 13 (in 3 animals) days after surgical implantation of 3x105 viable VX-2 tumor cells in the frontoparietal lobes. The CT studies were correlated with gross pathology in each. The tumor was visualized with CT in all 5 rabbits by the 9th day post implantation when the tumor ranged in size from 4-6x3-4x2-3 mm. Between the 9th and 13th day, the tumor increased 6-fold in two rabbits and 12-fold in the third rabbit. CT is a useful technique to evaluate brain tumor growth in this model and should be valuable in documenting the efficacy of chemotherapy on tumor growth.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalNeuroradiology
Volume28
Issue number1
DOIs
StatePublished - Dec 1986

Keywords

  • Rabbit brain Anatomy
  • Rabbit brain tumor
  • Sequential computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Kumar, A. J., Hassenbusch, S., Rosenbaum, A. E., Beck, T. J., Hadfield, R., Ahn, H. S., & Anderson, J. (1986). Sequential computed tomographic imaging of a transplantable rabbit brain tumor. Neuroradiology, 28(1), 81-86. https://doi.org/10.1007/BF00341774