Sequence variations in CREB1 cosegregate with depressive disorders in women

G. S. Zubenko, H. B. Hughes, J. S. Stiffler, A. Brechbiel, W. N. Zubenko, Brion Maher, M. L. Marazita

Research output: Contribution to journalArticle

Abstract

Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb region of 2q33-35 that exhibited significant evidence of linkage to Mood Disorders among women (but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly familial subtype of MDD. This 451kb region includes CREB1, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions.

Original languageEnglish (US)
Pages (from-to)611-618
Number of pages8
JournalMolecular Psychiatry
Volume8
Issue number6
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Major Depressive Disorder
Depressive Disorder
Mood Disorders
Introns
Genes
Public Health

Keywords

  • CREB1
  • Depression
  • Genetics
  • Sex-specific
  • Women

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Zubenko, G. S., Hughes, H. B., Stiffler, J. S., Brechbiel, A., Zubenko, W. N., Maher, B., & Marazita, M. L. (2003). Sequence variations in CREB1 cosegregate with depressive disorders in women. Molecular Psychiatry, 8(6), 611-618. https://doi.org/10.1038/sj.mp.4001354

Sequence variations in CREB1 cosegregate with depressive disorders in women. / Zubenko, G. S.; Hughes, H. B.; Stiffler, J. S.; Brechbiel, A.; Zubenko, W. N.; Maher, Brion; Marazita, M. L.

In: Molecular Psychiatry, Vol. 8, No. 6, 2003, p. 611-618.

Research output: Contribution to journalArticle

Zubenko, GS, Hughes, HB, Stiffler, JS, Brechbiel, A, Zubenko, WN, Maher, B & Marazita, ML 2003, 'Sequence variations in CREB1 cosegregate with depressive disorders in women', Molecular Psychiatry, vol. 8, no. 6, pp. 611-618. https://doi.org/10.1038/sj.mp.4001354
Zubenko, G. S. ; Hughes, H. B. ; Stiffler, J. S. ; Brechbiel, A. ; Zubenko, W. N. ; Maher, Brion ; Marazita, M. L. / Sequence variations in CREB1 cosegregate with depressive disorders in women. In: Molecular Psychiatry. 2003 ; Vol. 8, No. 6. pp. 611-618.
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