Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk

Xin Xi Zhou, Wei Hua Jia, Guo Ping Shen, Hai De Qin, Xing Juan Yu, Li Zhen Chen, Qi Sheng Feng, Yin Yao Shugart, Yi Xin Zeng

Research output: Contribution to journalArticle

Abstract

Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China and Southeast Asia. Genetic susceptibility is a major factor in determining the individual risk of NPC in these areas. To test the association between NPC and variants in Toll-like receptor 10 (TLR10), we conducted a hospital-based case-control study in a Cantonese-speaking population in Guangdong province. Seven single nucleotide polymorphisms in TLR10, selected with a tagging algorithm, were genotyped. When assessing each unique haplotype compared with the most common haplotype, "GAGTGAA," with the expectation- maximization algorithm in Haplo.stats, the risk of developing NPC was significantly elevated among men who carried the haplotype "GCGTGGC" (P = 0.005). After adjusting for age, gender, and VCA-IgA antibody titers, this association was more significant (P = 0.0007). To further assess the overall differences of haplotype frequency profiles between cases and healthy controls, the global score test, considering all haplotypes and adjusting for age, gender, and VCA-IgA antibody titers, gave a haplo score of 27.52 with P = 0.002. The haplotype specific odds ratio was 2.66 (confidence interval, 1.34-3.82) for GCGTGGC. We concluded that in this Cantonese population-based study, haplotype GCGTGGC with frequency of 11.4% in TLR10 was found to be associated with NPC and this association was statistically significant after adjusting for age, gender, and VCA-IgA antibody titers. It is possible that this is not a causal haplotype for NPC; rather, it is in strong linkage disequilibrium with a causal single nucleotide polymorphism in close proximity.

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number5
DOIs
Publication statusPublished - May 2006

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ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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