Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase

James D. Shull; Noriko Esumi; Amy S. Colwell; Karen L. Pennington; Moncef Jendoubi

doi:10.1016/0378-1119(95)00309-T

Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase

James D. Shull, Noriko Esumi, Amy S. Colwell, Karen L. Pennington, Moncef Jendoubi

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We have isolated and sequenced the promoter region of the mouse gene (mOAT) encoding ornithine aminotransferase. A comparison of these mOAT sequences with previously reported sequences for the rat and human genes encoding OAT, rOAT and hOAT, respectively, revealed a 256-bp region flanking the transcription start point that is highly conserved between the three genes. This region contains sequence motifs resembling binding sites for general transcription factors, as well as other trans-acting regulatory proteins.

Original language	English (US)
Pages (from-to)	275-277
Number of pages	3
Journal	Gene
Volume	162
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(95)00309-T
State	Published - Sep 11 1995
Externally published	Yes

Keywords

CRE
CRE-binding protein
CREB
Gene structure
OAT
UCE
base pair(s)
bp
cAMP-responsive element
gene encoding OAT
gyrate atrophy
hOAT
human OAT
humanOAT
kb
kilobase(s) or 1000 bp
mOAT
mouseOAT
nt
nucleotide sequence
nucleotide(s)
ornithine aminotransferase
rOAT
rat OAT
ratOAT
recombinant DNA
regulatory region
transcription start point(s)
tsp
urea cycle element(s)

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(95)00309-T

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@article{71d4b43a505242909f462ddcf000441b,

title = "Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase",

abstract = "We have isolated and sequenced the promoter region of the mouse gene (mOAT) encoding ornithine aminotransferase. A comparison of these mOAT sequences with previously reported sequences for the rat and human genes encoding OAT, rOAT and hOAT, respectively, revealed a 256-bp region flanking the transcription start point that is highly conserved between the three genes. This region contains sequence motifs resembling binding sites for general transcription factors, as well as other trans-acting regulatory proteins.",

keywords = "CRE, CRE-binding protein, CREB, Gene structure, OAT, UCE, base pair(s), bp, cAMP-responsive element, gene encoding OAT, gyrate atrophy, hOAT, human OAT, humanOAT, kb, kilobase(s) or 1000 bp, mOAT, mouseOAT, nt, nucleotide sequence, nucleotide(s), ornithine aminotransferase, rOAT, rat OAT, ratOAT, recombinant DNA, regulatory region, transcription start point(s), tsp, urea cycle element(s)",

author = "Shull, {James D.} and Noriko Esumi and Colwell, {Amy S.} and Pennington, {Karen L.} and Moncef Jendoubi",

note = "Funding Information: This work was supported by grants HD24189 and CA36727 from the National Institutes of Health and grant 94-42 from the Nebraska Cancer and Smoking Disease Research Program. We thank Drs. M.M. Mueckler and H.C. Pitot for providing the rOAT cDNA.",

year = "1995",

month = sep,

day = "11",

doi = "10.1016/0378-1119(95)00309-T",

language = "English (US)",

volume = "162",

pages = "275--277",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase

AU - Shull, James D.

AU - Esumi, Noriko

AU - Colwell, Amy S.

AU - Pennington, Karen L.

AU - Jendoubi, Moncef

N1 - Funding Information: This work was supported by grants HD24189 and CA36727 from the National Institutes of Health and grant 94-42 from the Nebraska Cancer and Smoking Disease Research Program. We thank Drs. M.M. Mueckler and H.C. Pitot for providing the rOAT cDNA.

PY - 1995/9/11

Y1 - 1995/9/11

N2 - We have isolated and sequenced the promoter region of the mouse gene (mOAT) encoding ornithine aminotransferase. A comparison of these mOAT sequences with previously reported sequences for the rat and human genes encoding OAT, rOAT and hOAT, respectively, revealed a 256-bp region flanking the transcription start point that is highly conserved between the three genes. This region contains sequence motifs resembling binding sites for general transcription factors, as well as other trans-acting regulatory proteins.

AB - We have isolated and sequenced the promoter region of the mouse gene (mOAT) encoding ornithine aminotransferase. A comparison of these mOAT sequences with previously reported sequences for the rat and human genes encoding OAT, rOAT and hOAT, respectively, revealed a 256-bp region flanking the transcription start point that is highly conserved between the three genes. This region contains sequence motifs resembling binding sites for general transcription factors, as well as other trans-acting regulatory proteins.

KW - CRE

KW - CRE-binding protein

KW - CREB

KW - Gene structure

KW - OAT

KW - UCE

KW - base pair(s)

KW - bp

KW - cAMP-responsive element

KW - gene encoding OAT

KW - gyrate atrophy

KW - hOAT

KW - human OAT

KW - humanOAT

KW - kb

KW - kilobase(s) or 1000 bp

KW - mOAT

KW - mouseOAT

KW - nt

KW - nucleotide sequence

KW - nucleotide(s)

KW - ornithine aminotransferase

KW - rOAT

KW - rat OAT

KW - ratOAT

KW - recombinant DNA

KW - regulatory region

KW - transcription start point(s)

KW - tsp

KW - urea cycle element(s)

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DO - 10.1016/0378-1119(95)00309-T

M3 - Article

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AN - SCOPUS:0029093748

SN - 0378-1119

VL - 162

SP - 275

EP - 277

JO - Gene

JF - Gene

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ER -

Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase

Abstract

Keywords

ASJC Scopus subject areas

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