Sequence learning and the role of the hippocampus in rodent navigation

David J. Foster, James J. Knierim

Research output: Contribution to journalReview articlepeer-review


The hippocampus has long been associated with navigation and spatial representations, but it has been difficult to link directly the neurophysiological correlates of hippocampal place cells with navigational planning and action. In recent years, large-scale population recordings of place cells have revealed that spatial sequences are stored and activated in ways that may support navigational strategies. Plasticity mechanisms allow the hippocampus to store learned sequences of locations that may allow predictions of future locations based on past experience. These sequences can also be activated during navigational behavior in ways that may allow the animal to learn trajectories toward goals. Task-dependent alterations in place cell firing patterns may reflect the operation of the hippocampus in associating locations with navigationally relevant decision variables.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number2
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Neuroscience(all)


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