Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus

Matthew A. Gonda, Flossie Wong-Staal, Robert C. Gallo, Janice E Clements, Opendra Narayan, Raymond V. Gilden

Research output: Contribution to journalArticle

Abstract

A study was conducted of the genetic relation between human T-cell lymphotropic retroviruses and visna virus. The human T-cell lymphotropic viruses include those associated with T-cell malignancies (HTLV-I and HTLV-II) as well as the etiologic agent of the acquired immune deficiency syndrome (HTLV-III). Visna virus, a slowly replicating and pathogenic but nononcogenic retrovirus of sheep, is a member of the subfamily Lentivirinae. Results obtained by molecular hybridization and heteroduplex analysis indicated that a greater extent of nucleotide sequence homology exists between HTLV-III and visna virus than between HTLV-III and any of the other viruses. The homology observed under conditions of low stringency spanned the entire genome, but was strongest in the gag/pol region. The morphogenesis and fine structure of HTLV-III and visna virus also demonstrated striking similarities. The data provide strong evidence for a close taxonomic and thus evolutionary relation between HTLV-III and the Lentivirinae subfamily.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalScience
Volume227
Issue number4683
StatePublished - 1985

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Visna-maedi virus
Deltaretrovirus
Lentivirus
Sequence Homology
HIV
Retroviridae
T-Lymphocytes
Heteroduplex Analysis
Human T-lymphotropic virus 2
Viruses
Human T-lymphotropic virus 1
Morphogenesis
Sheep
Acquired Immunodeficiency Syndrome
Genome
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Gonda, M. A., Wong-Staal, F., Gallo, R. C., Clements, J. E., Narayan, O., & Gilden, R. V. (1985). Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science, 227(4683), 173-177.

Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. / Gonda, Matthew A.; Wong-Staal, Flossie; Gallo, Robert C.; Clements, Janice E; Narayan, Opendra; Gilden, Raymond V.

In: Science, Vol. 227, No. 4683, 1985, p. 173-177.

Research output: Contribution to journalArticle

Gonda, MA, Wong-Staal, F, Gallo, RC, Clements, JE, Narayan, O & Gilden, RV 1985, 'Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus', Science, vol. 227, no. 4683, pp. 173-177.
Gonda MA, Wong-Staal F, Gallo RC, Clements JE, Narayan O, Gilden RV. Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science. 1985;227(4683):173-177.
Gonda, Matthew A. ; Wong-Staal, Flossie ; Gallo, Robert C. ; Clements, Janice E ; Narayan, Opendra ; Gilden, Raymond V. / Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. In: Science. 1985 ; Vol. 227, No. 4683. pp. 173-177.
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