Sequence analysis of the human genome: Implications for the understanding of nervous system function and disease

Anibal Cravchik, G. Subramanian, Samuel Broder, J. Craig Venter

Research output: Contribution to journalArticle

Abstract

The recent publication of the sequence of the human genome will accelerate the discovery of new genetic susceptibility factors for human disease, leading to the development of novel diagnostics and therapeutics. The exhaustive analysis of the human genome sequence will be the focus of the biomedical research community for many years to come. In particular, comparative analysis of the available eukaryotic genome sequences is an important approach to further our understanding of gene structure, function, and evolution. Our initial analysis of the human genome sequence has revealed many interesting features that are relevant to nervous system function, evolution, and disease. We analyzed the prominent features of predicted human proteins involved in neuronal function and prepared a comparative analysis of 146 human genes that have alleles (or mutations) conferring susceptibility for 168 neurologic diseases.

Original languageEnglish (US)
Pages (from-to)1772-1778
Number of pages7
JournalArchives of neurology
Volume58
Issue number11
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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