Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Epithelial cells have the ability to regulate paracellular permeability dynamically in response to extracellular stimuli. With every respiratory effort, airway epithelial cells are exposed to both physiologic as well as pathologic stimuli, and regulation of the epithelial barrier in response to these stimuli is crucial to respiratory function. We report that increased membrane septin-2 localization mediates decreases in paracellular permeability by altering cortical actin arrangement in human airway epithelial cells. This phenomenon occurs in response to both physiologic levels of shear stress and a pathologic stimulus, particular matter exposure. The resulting changes in barrier function in response to septin-2 redistribution have a significant impact on the ability of the apical ligand, epidermal growth factor, to interact with its receptor, epidermal growth factor receptor, which is segregated to the basolateral side in airway epithelial cells. This suggests that the dynamic regulation of the epithelial barrier function is essential in regulating signaling responses to extracellular stimuli. These findings indicate that septin-2 plays a fundamental role in regulating barrier function by altering cortical actin expression.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalAmerican journal of respiratory cell and molecular biology
Issue number1
StatePublished - Jul 1 2011


  • Actin cytoskeleton
  • Epithelial barrier function
  • Paracellular permeability
  • Septin-2

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology


Dive into the research topics of 'Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions'. Together they form a unique fingerprint.

Cite this