Abstract
Sepsis-associated encephalopathy is associated with increased mortality and morbidity. Its pathophysiology remains insufficiently elucidated, although there is evidence for a neuroinflammatory process sequentially involving endothelial activation, blood-brain barrier alteration and cellular dysfunction and alteration in neurotransmission. Experimental studies have shown that microcirculatory dysfunction, a consequence of endothelial activation, is an early pathogenic step. To date, we do not know whether it is present in septic patients, whether it accounts for clinical features and whether it is treatable.
Original language | English (US) |
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Article number | 199 |
Journal | Critical Care |
Volume | 14 |
Issue number | 5 |
DOIs |
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State | Published - Sep 29 2010 |
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine