Separation anxiety: Stress, tension and cytokinesis

Research output: Contribution to journalReview article

Abstract

Cytokinesis, the physical separation of a mother cell into two daughter cells, progresses through a series of well-defined changes in morphology. These changes involve distinct biochemical and mechanical processes. Here, we review the mechanical features of cells during cytokinesis, discussing both the material properties as well as sources of stresses, both active and passive, which lead to the observed changes in morphology. We also describe a mechanosensory feedback control system that regulates protein localization and shape progression during cytokinesis.

Original languageEnglish (US)
Pages (from-to)1428-1434
Number of pages7
JournalExperimental cell research
Volume318
Issue number12
DOIs
StatePublished - Jul 15 2012

Keywords

  • Actin dynamics
  • Cell division
  • Cell mechanics
  • Cleavage furrow
  • Mechanosensation
  • Myosin II

ASJC Scopus subject areas

  • Cell Biology

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