TY - JOUR
T1 - Separation anxiety disorder in OCD
AU - Mroczkowski, Megan M.
AU - Goes, Fernando S.
AU - Riddle, Mark A.
AU - Grados, Marco A.
AU - Bienvenu, O. Joseph
AU - Greenberg, Benjamin D.
AU - Fyer, Abby J.
AU - McCracken, James T.
AU - Rauch, Scott L.
AU - Murphy, Dennis L.
AU - Knowles, James A.
AU - Piacentini, John
AU - Cullen, Bernadette
AU - Rasmussen, Steven A.
AU - Geller, Daniel A.
AU - Pauls, David L.
AU - Liang, Kung Yee
AU - Nestadt, Gerald
AU - Samuels, Jack F.
PY - 2011/3
Y1 - 2011/3
N2 - Background: A history of separation anxiety disorder (SAD) is frequently reported by patients with obsessive-compulsive disorder (OCD). The purpose of this study was to determine if there are clinical differences between OCD-affected individuals with, versus without, a history of SAD. Methods: Using data collected during the OCD Collaborative Genetic Study, we studied 470 adult OCD participants; 80 had a history of SAD, whereas 390 did not.These two groups were compared as to onset and severity of OCD, lifetime prevalence of Axis I disorders, and number of personality disorder traits. Results: OCD participants with a history of SAD were significantly younger than the non-SAD group (mean, 34.2 versus 42.2 years; P<.001). They had an earlier age of onset of OCD symptoms (mean, 8.0 versus 10.5 years; P<.003) and more severe OCD, as measured by the Yale-Brown Obsessive Compulsive Scale (mean, 27.5 versus 25.0; P<.005). In addition, those with a history of SAD had a significantly greater lifetime prevalence of agoraphobia (odds ratio (OR)=2.52, 95% confidence interval (CI)=1.4-4.6, P<.003), panic disorder (OR=1.84, CI=1.03-3.3 P<.04), social phobia (OR=1.69, CI 1.01-2.8, P<.048), after adjusting for age at interview, age at onset of OCD, and OCD severity in logistic regression models. There was a strong relationship between the number of dependent personality disorder traits and SAD (adjusted OR=1.42, CI=1.2-1.6, P<.001). Conclusions: A history of SAD is associated with anxiety disorders and dependent personality disorder traits in individuals with OCD.
AB - Background: A history of separation anxiety disorder (SAD) is frequently reported by patients with obsessive-compulsive disorder (OCD). The purpose of this study was to determine if there are clinical differences between OCD-affected individuals with, versus without, a history of SAD. Methods: Using data collected during the OCD Collaborative Genetic Study, we studied 470 adult OCD participants; 80 had a history of SAD, whereas 390 did not.These two groups were compared as to onset and severity of OCD, lifetime prevalence of Axis I disorders, and number of personality disorder traits. Results: OCD participants with a history of SAD were significantly younger than the non-SAD group (mean, 34.2 versus 42.2 years; P<.001). They had an earlier age of onset of OCD symptoms (mean, 8.0 versus 10.5 years; P<.003) and more severe OCD, as measured by the Yale-Brown Obsessive Compulsive Scale (mean, 27.5 versus 25.0; P<.005). In addition, those with a history of SAD had a significantly greater lifetime prevalence of agoraphobia (odds ratio (OR)=2.52, 95% confidence interval (CI)=1.4-4.6, P<.003), panic disorder (OR=1.84, CI=1.03-3.3 P<.04), social phobia (OR=1.69, CI 1.01-2.8, P<.048), after adjusting for age at interview, age at onset of OCD, and OCD severity in logistic regression models. There was a strong relationship between the number of dependent personality disorder traits and SAD (adjusted OR=1.42, CI=1.2-1.6, P<.001). Conclusions: A history of SAD is associated with anxiety disorders and dependent personality disorder traits in individuals with OCD.
KW - Obsessive-compulsive disorder
KW - Personality disorders
KW - Separation anxiety disorder
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U2 - 10.1002/da.20773
DO - 10.1002/da.20773
M3 - Article
C2 - 21308883
AN - SCOPUS:79952579980
SN - 1091-4269
VL - 28
SP - 256
EP - 262
JO - Depression and anxiety
JF - Depression and anxiety
IS - 3
ER -