Separate neural bases of two fundamental memory processes in the human medial temporal lobe

John D E Gabrieli, James B. Brewer, John Desmond, Gary H. Glover

Research output: Contribution to journalArticle

Abstract

The participation of medial temporal-lobe structures in memory performance was examined by functional magnetic resonance imaging of local blood oxygenation level-dependent signals. Signals were measured during encoding into memory complex scenes or line drawings and during retrieval from memory of previously studied line drawings or words. Encoding tasks yielded increased signals for unfamiliar information in a posterior medial- temporal region that were focused in the parahippocampal cortex. Retrieval tasks yielded increased signals for successfully remembered information in an anterior medial-temporal region that were focused in the subiculum. These results indicate that separate components of the human medial temporal-lobe memory system are active during distinct memory processes.

Original languageEnglish (US)
Pages (from-to)264-266
Number of pages3
JournalScience
Volume276
Issue number5310
DOIs
StatePublished - Apr 11 1997
Externally publishedYes

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Temporal Lobe
Hippocampus
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • General

Cite this

Separate neural bases of two fundamental memory processes in the human medial temporal lobe. / Gabrieli, John D E; Brewer, James B.; Desmond, John; Glover, Gary H.

In: Science, Vol. 276, No. 5310, 11.04.1997, p. 264-266.

Research output: Contribution to journalArticle

Gabrieli, John D E ; Brewer, James B. ; Desmond, John ; Glover, Gary H. / Separate neural bases of two fundamental memory processes in the human medial temporal lobe. In: Science. 1997 ; Vol. 276, No. 5310. pp. 264-266.
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