Sentinel lymph node positivity of patients with ductal carcinoma in situ or microinvasive breast cancer

Angela Katz, Irene Gage, Sheila Evans, Margaret Shaffer, Thomas Fleury, Frederick P. Smith, Richard Flax, Cynthia Drogula, Peter Petrucci, Colette Magnant

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The purpose of this study was to determine the rates of sentinel lymph node (SLN) positivity in patients with a final diagnosis of ductal carcinoma in situ (DCIS) or microinvasive breast cancer (MIC). Methods: One hundred thirty patients underwent SLN mapping from 1998 to 2003 for DCIS or MIC. Results: One hundred nine patients with DCIS and 21 with MIC underwent SLN mapping. One patient with bilateral DCIS underwent 2 SLN procedures; therefore, the results of 131 SLN procedures are included. On hematoxylin and eosin (H&E) staining, 4 of 110 patients (3.6%) with DCIS had positive SLNs. Four additional patients had positive SLNs by IHC staining only (3.6%). Two of 8 patients underwent completion axillary dissection, and neither had additional involved nodes on completion axillary dissection. One of the 21 patients with MIC had positive SLNs by hematoxylin and eosin (H&E) (4.8%), and another had an involved SLN by IHC staining (4.8%). The patient with the positive SLN by H&E had 1 additional node on completion axillary dissection. Conclusion: Rates of SLN positivity for patients with DCIS are modest, even in a high-risk population, and there is continuing uncertainty about its clinical importance.

Original languageEnglish (US)
Pages (from-to)761-766
Number of pages6
JournalAmerican journal of surgery
Volume191
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Ductal carcinoma in situ
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery

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