Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study

Lun De Liao, Yu Hang Liu, Aishwarya Bandla, Ji Min Ling, Hsin Yi Lai, You Yin Chen, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Study of cerebral cortical functions affected by ischemic stroke explicates post-stroke brain plasticity. We report an innovative combination of electrocorticography (ECoG) recordings and functional photoacoustic microscopy (fPAM) imaging to investigate cortical functions after photothrombotic ischemia (PTI) in rat brain, with electrical forepaw stimulation applied as treatment. The cortical functions were assessed over a chosen ischemic region via somatosensoryevoked potential (SSEP), resting-state ECoG signals and evoked hemodynamic response. Two-phased experimental protocols based on sensory stimulation treatment are proposed and performed in this study. In the phase 1, the treatment is applied to the left forepaw, contralateral to the ischemic hemisphere, with 2 mA pulses initiated 0, 1, or 2 hours postischemia to determine optimal onset timing. After determining the optimal time window, in the phase 2, the treatment was delivered unilaterally or bilaterally using 2 or 4 mA pulses for validating if bilateral peripheral electrical stimulation with different current intensities could improve cerebral perfusion and restore cortical neurovascular response. Overall, the results demonstrated that our treatment administered bilaterally at 2 mA within 2 hours of ischemia can promote neuroprotection significantly via reversed cortical functions, suggesting effective recovery.

Original languageEnglish (US)
Title of host publication1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
PublisherSpringer Verlag
Pages256-259
Number of pages4
Volume47
ISBN (Print)9783319122618
DOIs
StatePublished - 2015
Event1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan, Province of China
Duration: Oct 9 2014Oct 12 2014

Other

Other1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
CountryTaiwan, Province of China
CityTainan
Period10/9/1410/12/14

Fingerprint

Imaging techniques
Brain
Photoacoustic microscopy
Hemodynamics
Plasticity
Rats
Recovery

Keywords

  • ECoG
  • FPAM
  • Neuroprotection
  • Photothrombotic ischemia (PTI)
  • Sensory stimulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Liao, L. D., Liu, Y. H., Bandla, A., Ling, J. M., Lai, H. Y., Chen, Y. Y., & Thakor, N. V. (2015). Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study. In 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering (Vol. 47, pp. 256-259). Springer Verlag. https://doi.org/10.1007/978-3-319-11128-5_71

Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study. / Liao, Lun De; Liu, Yu Hang; Bandla, Aishwarya; Ling, Ji Min; Lai, Hsin Yi; Chen, You Yin; Thakor, Nitish V.

1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. Vol. 47 Springer Verlag, 2015. p. 256-259.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liao, LD, Liu, YH, Bandla, A, Ling, JM, Lai, HY, Chen, YY & Thakor, NV 2015, Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study. in 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. vol. 47, Springer Verlag, pp. 256-259, 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014, Tainan, Taiwan, Province of China, 10/9/14. https://doi.org/10.1007/978-3-319-11128-5_71
Liao LD, Liu YH, Bandla A, Ling JM, Lai HY, Chen YY et al. Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study. In 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. Vol. 47. Springer Verlag. 2015. p. 256-259 https://doi.org/10.1007/978-3-319-11128-5_71
Liao, Lun De ; Liu, Yu Hang ; Bandla, Aishwarya ; Ling, Ji Min ; Lai, Hsin Yi ; Chen, You Yin ; Thakor, Nitish V. / Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study. 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. Vol. 47 Springer Verlag, 2015. pp. 256-259
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