Sensory nerves and airway irritability

B. J. Canning, D. Spina

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The lung, like many other organs, is innervated by a variety of sensory nerves and by nerves of the parasympathetic and sympathetic nervous systems that regulate the function of cells within the respiratory tract. Activation of sensory nerves by both mechanical and chemical stimuli elicits a number of defensive reflexes, including cough, altered breathing pattern, and altered autonomic drive, which are important for normal lung homeostasis. However, diseases that afflict the lung are associated with altered reflexes, resulting in a variety of symptoms, including increased cough, dyspnea, airways obstruction, and bronchial hyperresponsiveness. This review summarizes the current knowledge concerning the physiological role of different sensory nerve subtypes that innervate the lung, the factors which lead to their activation, and pharmacological approaches that have been used to interrogate the function of these nerves. This information may potentially facilitate the identification of novel drug targets for the treatment of respiratory disorders such as cough, asthma, and chronic obstructive pulmonary disease.

Original languageEnglish (US)
Title of host publicationHandbook of Experimental Pharmacology
EditorsBrendan Canning, Domenico Spina
Pages139-183
Number of pages45
DOIs
StatePublished - 2009

Publication series

NameHandbook of Experimental Pharmacology
Volume194
ISSN (Print)0171-2004

Keywords

  • Bronchial hyperresponsiveness
  • Bronchoconstriction
  • C-fibers
  • Cough
  • Cough receptor
  • Mucus secretion
  • Parasympathetic nervous system
  • Rapidly adapting receptors
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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