Sensory and motor peripheral nerve function and incident mobility disability

Rachel E. Ward; Robert M. Boudreau; Paolo Caserotti; Tamara B. Harris; Sasa Zivkovic; Bret H. Goodpaster; Suzanne Satterfield; Stephen B. Kritchevsky; Ann V. Schwartz; Aaron I. Vinik; Jane A. Cauley; Eleanor M. Simonsick; Anne B. Newman; Elsa S. Strotmeyer

doi:10.1111/jgs.13152

Sensory and motor peripheral nerve function and incident mobility disability

Rachel E. Ward, Robert M. Boudreau, Paolo Caserotti, Tamara B. Harris, Sasa Zivkovic, Bret H. Goodpaster, Suzanne Satterfield, Stephen B. Kritchevsky, Ann V. Schwartz, Aaron I. Vinik, Jane A. Cauley, Eleanor M. Simonsick, Anne B. Newman, Elsa S. Strotmeyer

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objectives To assess the relationship between sensorimotor nerve function and incident mobility disability over 10 years.

Design Prospective cohort study with longitudinal analysis.

Setting Two U.S. clinical sites.

Participants Population-based sample of community-dwelling older adults with no mobility disability at 2000/01 examination (N = 1,680; mean age ± SD 76.5 ± 2.9, body mass index 27.1 ± 4.6; 50.2% female, 36.6% black, 10.7% with diabetes mellitus).

Measurements Motor nerve conduction amplitude (poor <1 mV) and velocity (poor <40 m/s) were measured on the deep peroneal nerve. Sensory nerve function was measured using 10- and 1.4-g monofilaments and vibration detection threshold at the toe. Lower extremity symptoms included numbness or tingling and aching or burning pain. Incident mobility disability assessed semiannually over 8.5 years (interquartile range 4.5-9.6 years) was defined as two consecutive self-reports of a lot of difficulty or inability to walk one-quarter of a mile or climb 10 steps.

Results Nerve impairments were detected in 55% of participants, and 30% developed mobility disability. Worse motor amplitude (HR = 1.29 per SD, 95% CI = 1.16-1.44), vibration detection threshold (HR = 1.13 per SD, 95% CI = 1.04-1.23), symptoms (HR = 1.65, 95% CI = 1.26-2.17), two motor impairments (HR = 2.10, 95% CI = 1.43-3.09), two sensory impairments (HR = 1.91, 95% CI = 1.37-2.68), and three or more nerve impairments (HR = 2.33, 95% CI = 1.54-3.53) predicted incident mobility disability after adjustment. Quadriceps strength mediated relationships between certain nerve impairments and mobility disability, although most remained significant.

Conclusion Poor sensorimotor nerve function independently predicted mobility disability. Future work should investigate modifiable risk factors and interventions such as strength training for preventing disability and improving function in older adults with poor nerve function.

Original language	English (US)
Pages (from-to)	2273-2279
Number of pages	7
Journal	Journal of the American Geriatrics Society
Volume	62
Issue number	12
DOIs	https://doi.org/10.1111/jgs.13152
State	Published - Dec 1 2014

Keywords

disability
longitudinal analysis
muscle strength
older adults
peripheral nerve function

ASJC Scopus subject areas

Geriatrics and Gerontology

Access to Document

10.1111/jgs.13152

Cite this

Ward, R. E., Boudreau, R. M., Caserotti, P., Harris, T. B., Zivkovic, S., Goodpaster, B. H., Satterfield, S., Kritchevsky, S. B., Schwartz, A. V., Vinik, A. I., Cauley, J. A., Simonsick, E. M., Newman, A. B., & Strotmeyer, E. S. (2014). Sensory and motor peripheral nerve function and incident mobility disability. Journal of the American Geriatrics Society, 62(12), 2273-2279. https://doi.org/10.1111/jgs.13152

Ward, RE, Boudreau, RM, Caserotti, P, Harris, TB, Zivkovic, S, Goodpaster, BH, Satterfield, S, Kritchevsky, SB, Schwartz, AV, Vinik, AI, Cauley, JA, Simonsick, EM, Newman, AB & Strotmeyer, ES 2014, 'Sensory and motor peripheral nerve function and incident mobility disability', Journal of the American Geriatrics Society, vol. 62, no. 12, pp. 2273-2279. https://doi.org/10.1111/jgs.13152

@article{0aa9859c5bca4b04913227b51dc85eab,

title = "Sensory and motor peripheral nerve function and incident mobility disability",

abstract = "Objectives To assess the relationship between sensorimotor nerve function and incident mobility disability over 10 years.Design Prospective cohort study with longitudinal analysis.Setting Two U.S. clinical sites.Participants Population-based sample of community-dwelling older adults with no mobility disability at 2000/01 examination (N = 1,680; mean age ± SD 76.5 ± 2.9, body mass index 27.1 ± 4.6; 50.2% female, 36.6% black, 10.7% with diabetes mellitus).Measurements Motor nerve conduction amplitude (poor <1 mV) and velocity (poor <40 m/s) were measured on the deep peroneal nerve. Sensory nerve function was measured using 10- and 1.4-g monofilaments and vibration detection threshold at the toe. Lower extremity symptoms included numbness or tingling and aching or burning pain. Incident mobility disability assessed semiannually over 8.5 years (interquartile range 4.5-9.6 years) was defined as two consecutive self-reports of a lot of difficulty or inability to walk one-quarter of a mile or climb 10 steps.Results Nerve impairments were detected in 55% of participants, and 30% developed mobility disability. Worse motor amplitude (HR = 1.29 per SD, 95% CI = 1.16-1.44), vibration detection threshold (HR = 1.13 per SD, 95% CI = 1.04-1.23), symptoms (HR = 1.65, 95% CI = 1.26-2.17), two motor impairments (HR = 2.10, 95% CI = 1.43-3.09), two sensory impairments (HR = 1.91, 95% CI = 1.37-2.68), and three or more nerve impairments (HR = 2.33, 95% CI = 1.54-3.53) predicted incident mobility disability after adjustment. Quadriceps strength mediated relationships between certain nerve impairments and mobility disability, although most remained significant.Conclusion Poor sensorimotor nerve function independently predicted mobility disability. Future work should investigate modifiable risk factors and interventions such as strength training for preventing disability and improving function in older adults with poor nerve function.",

keywords = "disability, longitudinal analysis, muscle strength, older adults, peripheral nerve function",

author = "Ward, {Rachel E.} and Boudreau, {Robert M.} and Paolo Caserotti and Harris, {Tamara B.} and Sasa Zivkovic and Goodpaster, {Bret H.} and Suzanne Satterfield and Kritchevsky, {Stephen B.} and Schwartz, {Ann V.} and Vinik, {Aaron I.} and Cauley, {Jane A.} and Simonsick, {Eleanor M.} and Newman, {Anne B.} and Strotmeyer, {Elsa S.}",

note = "Publisher Copyright: {\textcopyright} 2014, The American Geriatrics Society.",

year = "2014",

month = dec,

day = "1",

doi = "10.1111/jgs.13152",

language = "English (US)",

volume = "62",

pages = "2273--2279",

journal = "Journal of the American Geriatrics Society",

issn = "0002-8614",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Sensory and motor peripheral nerve function and incident mobility disability

AU - Ward, Rachel E.

AU - Boudreau, Robert M.

AU - Caserotti, Paolo

AU - Harris, Tamara B.

AU - Zivkovic, Sasa

AU - Goodpaster, Bret H.

AU - Satterfield, Suzanne

AU - Kritchevsky, Stephen B.

AU - Schwartz, Ann V.

AU - Vinik, Aaron I.

AU - Cauley, Jane A.

AU - Simonsick, Eleanor M.

AU - Newman, Anne B.

AU - Strotmeyer, Elsa S.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objectives To assess the relationship between sensorimotor nerve function and incident mobility disability over 10 years.Design Prospective cohort study with longitudinal analysis.Setting Two U.S. clinical sites.Participants Population-based sample of community-dwelling older adults with no mobility disability at 2000/01 examination (N = 1,680; mean age ± SD 76.5 ± 2.9, body mass index 27.1 ± 4.6; 50.2% female, 36.6% black, 10.7% with diabetes mellitus).Measurements Motor nerve conduction amplitude (poor <1 mV) and velocity (poor <40 m/s) were measured on the deep peroneal nerve. Sensory nerve function was measured using 10- and 1.4-g monofilaments and vibration detection threshold at the toe. Lower extremity symptoms included numbness or tingling and aching or burning pain. Incident mobility disability assessed semiannually over 8.5 years (interquartile range 4.5-9.6 years) was defined as two consecutive self-reports of a lot of difficulty or inability to walk one-quarter of a mile or climb 10 steps.Results Nerve impairments were detected in 55% of participants, and 30% developed mobility disability. Worse motor amplitude (HR = 1.29 per SD, 95% CI = 1.16-1.44), vibration detection threshold (HR = 1.13 per SD, 95% CI = 1.04-1.23), symptoms (HR = 1.65, 95% CI = 1.26-2.17), two motor impairments (HR = 2.10, 95% CI = 1.43-3.09), two sensory impairments (HR = 1.91, 95% CI = 1.37-2.68), and three or more nerve impairments (HR = 2.33, 95% CI = 1.54-3.53) predicted incident mobility disability after adjustment. Quadriceps strength mediated relationships between certain nerve impairments and mobility disability, although most remained significant.Conclusion Poor sensorimotor nerve function independently predicted mobility disability. Future work should investigate modifiable risk factors and interventions such as strength training for preventing disability and improving function in older adults with poor nerve function.

AB - Objectives To assess the relationship between sensorimotor nerve function and incident mobility disability over 10 years.Design Prospective cohort study with longitudinal analysis.Setting Two U.S. clinical sites.Participants Population-based sample of community-dwelling older adults with no mobility disability at 2000/01 examination (N = 1,680; mean age ± SD 76.5 ± 2.9, body mass index 27.1 ± 4.6; 50.2% female, 36.6% black, 10.7% with diabetes mellitus).Measurements Motor nerve conduction amplitude (poor <1 mV) and velocity (poor <40 m/s) were measured on the deep peroneal nerve. Sensory nerve function was measured using 10- and 1.4-g monofilaments and vibration detection threshold at the toe. Lower extremity symptoms included numbness or tingling and aching or burning pain. Incident mobility disability assessed semiannually over 8.5 years (interquartile range 4.5-9.6 years) was defined as two consecutive self-reports of a lot of difficulty or inability to walk one-quarter of a mile or climb 10 steps.Results Nerve impairments were detected in 55% of participants, and 30% developed mobility disability. Worse motor amplitude (HR = 1.29 per SD, 95% CI = 1.16-1.44), vibration detection threshold (HR = 1.13 per SD, 95% CI = 1.04-1.23), symptoms (HR = 1.65, 95% CI = 1.26-2.17), two motor impairments (HR = 2.10, 95% CI = 1.43-3.09), two sensory impairments (HR = 1.91, 95% CI = 1.37-2.68), and three or more nerve impairments (HR = 2.33, 95% CI = 1.54-3.53) predicted incident mobility disability after adjustment. Quadriceps strength mediated relationships between certain nerve impairments and mobility disability, although most remained significant.Conclusion Poor sensorimotor nerve function independently predicted mobility disability. Future work should investigate modifiable risk factors and interventions such as strength training for preventing disability and improving function in older adults with poor nerve function.

KW - disability

KW - longitudinal analysis

KW - muscle strength

KW - older adults

KW - peripheral nerve function

UR - http://www.scopus.com/inward/record.url?scp=84918776863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918776863&partnerID=8YFLogxK

U2 - 10.1111/jgs.13152

DO - 10.1111/jgs.13152

M3 - Article

C2 - 25482096

AN - SCOPUS:84918776863

SN - 0002-8614

VL - 62

SP - 2273

EP - 2279

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

IS - 12

ER -

Sensory and motor peripheral nerve function and incident mobility disability

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this