Sensitization profiles to peanut allergens across the United States

Andre Valcour, Joseph E. Jones, Jonas Lidholm, Magnus P. Borres, Robert G Hamilton

Research output: Contribution to journalArticle


METHODS: Serum samples from 12,155 individuals with peanut extract specific IgE levels of 0.35 kUA/L or higher were analyzed for IgE antibodies to Ara h 1, 2, 3, 8, and 9 by ImmunoCAP.

RESULTS: Among this population of peanut sensitized individuals, 79.1% of children (<3 years old) were sensitized to one or more peanut storage proteins (Ara h 1, 2, and/or 3), in contrast to 64.2% of adolescents (12-15 years old) and 22.1% of adults (>20 years old). Although sensitization was more prevalent to Ara h 2 than to the other storage proteins, a sizable fraction of patients were sensitized to Ara h 1 and/or 3 but not to Ara h 2 (eg, 13% of children <3 years old). Moreover, 9.6% of children, 10.2% of adolescents, and 10.5% of adults were sensitized to Ara h 9, whereas 2.4% of children, 49.4% of adolescents, and 42.9% of adults produced IgE to Ara h 8 (pathogenesis-related protein 10). Sensitization to Ara h 8 alone was markedly higher in the Northeastern United States relative to other regions of the country.

CONCLUSION: We conclude that sensitization to individual peanut components is highly dependent on age and geographic location. Given that a severe allergic reaction to peanut is unlikely in individuals with isolated sensitization to Ara h 8, a sizable fraction of patients, in particular adolescents and adults, may be at lower risk than anticipated based only on demonstration of sensitization to whole peanut extract.

BACKGROUND: Measurement of IgE antibody to peanut components can aid in the prediction of allergic responses the food.

OBJECTIVE: To investigate the association between patient demographics (age, location) and allergic sensitization to peanut components across the United States.

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Issue number3
StatePublished - Sep 1 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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