Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials

Lawrence Scahill, Denis G. Sukhodolsky, Emily Anderberg, Anastasia Dimitropoulos, James Dziura, Michael G. Aman, James McCracken, Elaine Tierney, Victoria Hallett, Karol Katz, Benedetto Vitiello, Christopher McDougle

Research output: Contribution to journalArticle

Abstract

Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4-17 years). At the medication-free baseline, the internal consistency on the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach's alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74-0.88). There were no differences between active treatment groups. These results indicate that the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test-retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalAutism
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2016

    Fingerprint

Keywords

  • autism spectrum disorder
  • clinical trials
  • outcome measurement
  • repetitive behavior
  • risperidone

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Scahill, L., Sukhodolsky, D. G., Anderberg, E., Dimitropoulos, A., Dziura, J., Aman, M. G., McCracken, J., Tierney, E., Hallett, V., Katz, K., Vitiello, B., & McDougle, C. (2016). Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism, 20(2), 145-152. https://doi.org/10.1177/1362361315574889