Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

H. P. Ho, W. Yuan, C. L. Wong, S. Y. Wu, Y. K. Suen, S. K. Kong, Chinlon Lin

Research output: Contribution to journalArticlepeer-review

Abstract

A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalOptics Communications
Volume275
Issue number2
DOIs
StatePublished - Jul 15 2007
Externally publishedYes

Keywords

  • Biosensor
  • Fabry-Perot interferometry
  • Phase interrogation
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry
  • Electrical and Electronic Engineering

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