Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

H. P. Ho; W. Yuan; C. L. Wong; S. Y. Wu; Y. K. Suen; S. K. Kong; Chinlon Lin

doi:10.1016/j.optcom.2007.03.067

Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

H. P. Ho, W. Yuan, C. L. Wong, S. Y. Wu, Y. K. Suen, S. K. Kong, Chinlon Lin

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.

Original language	English (US)
Pages (from-to)	491-496
Number of pages	6
Journal	Optics Communications
Volume	275
Issue number	2
DOIs	https://doi.org/10.1016/j.optcom.2007.03.067
State	Published - Jul 15 2007
Externally published	Yes

Keywords

Biosensor
Fabry-Perot interferometry
Phase interrogation
Surface plasmon resonance

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry
Electrical and Electronic Engineering

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10.1016/j.optcom.2007.03.067

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title = "Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor",

abstract = "A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.",

keywords = "Biosensor, Fabry-Perot interferometry, Phase interrogation, Surface plasmon resonance",

author = "Ho, {H. P.} and W. Yuan and Wong, {C. L.} and Wu, {S. Y.} and Suen, {Y. K.} and Kong, {S. K.} and Chinlon Lin",

note = "Funding Information: This work has been supported by RGC grant (CUHK4186/04E). The work on aptamer has been supported by a CUHK direct grant (#2030299). Partial funding support from Shun Hing Institute for Advanced Engineering, CUHK, and research studentships from CUHK for W. Yuan and S. Y. Wu are also gratefully acknowledged. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = jul,

day = "15",

doi = "10.1016/j.optcom.2007.03.067",

language = "English (US)",

volume = "275",

pages = "491--496",

journal = "Optics Communications",

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publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

AU - Ho, H. P.

AU - Yuan, W.

AU - Wong, C. L.

AU - Wu, S. Y.

AU - Suen, Y. K.

AU - Kong, S. K.

AU - Lin, Chinlon

N1 - Funding Information: This work has been supported by RGC grant (CUHK4186/04E). The work on aptamer has been supported by a CUHK direct grant (#2030299). Partial funding support from Shun Hing Institute for Advanced Engineering, CUHK, and research studentships from CUHK for W. Yuan and S. Y. Wu are also gratefully acknowledged. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/7/15

Y1 - 2007/7/15

N2 - A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.

AB - A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.

KW - Biosensor

KW - Fabry-Perot interferometry

KW - Phase interrogation

KW - Surface plasmon resonance

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DO - 10.1016/j.optcom.2007.03.067

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SN - 0030-4018

VL - 275

SP - 491

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JO - Optics Communications

JF - Optics Communications

IS - 2

ER -

Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

Abstract

Keywords

ASJC Scopus subject areas

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