Senile plaques in cortex of aged normal monkeys

Robert G. Struble, Donald L. Price, Linda C. Cork, Donald L. Price

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


The density, type, and distributions of cortical senile plaques were determined in 6 aged rhesus monkeys. Plaque densities were highest in prefrontal and temporal cortices and lowest in occipital cortex. Neurite plaques contained many argentophilic neurites and little amyloid, mixed plaques had both neurites and amyloid, and amyloid plaques showed significant amounts of amyloid and fewer numbers of neurites. As total plaque densiry increased, there was a linear increase in the density of amyloid plaques, suggesting that plaques evolve from neurite, to mixed, to amyloid types.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalBrain research
Issue number1-2
StatePublished - Dec 30 1985


  • Alzheimer's disease
  • monkey
  • normal aging
  • senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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