Senile plaques in aged squirrel monkeys

Lary C. Walker, Cheryl A. Kitt, Elias Schwam, Beth Buckwald, Felix Garcia, Jerry Sepinwall, Donald L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalNeurobiology of Aging
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1987

Keywords

  • Alzheimer's disease
  • Amyloid Cytoskeleton
  • Neuropeptide Y
  • Primates

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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