Senile plaques in aged squirrel monkeys

Lary C. Walker; Cheryl A. Kitt; Elias Schwam; Beth Buckwald; Felix Garcia; Jerry Sepinwall; Donald L. Price

doi:10.1016/0197-4580(87)90067-4

Senile plaques in aged squirrel monkeys

Lary C. Walker, Cheryl A. Kitt, Elias Schwam, Beth Buckwald, Felix Garcia, Jerry Sepinwall, Donald L. Price

School of Medicine

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.

Original language	English (US)
Pages (from-to)	291-296
Number of pages	6
Journal	Neurobiology of aging
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0197-4580(87)90067-4
State	Published - 1987

Keywords

Alzheimer's disease
Amyloid Cytoskeleton
Neuropeptide Y
Primates

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(87)90067-4

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title = "Senile plaques in aged squirrel monkeys",

abstract = "Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.",

keywords = "Alzheimer's disease, Amyloid Cytoskeleton, Neuropeptide Y, Primates",

author = "Walker, {Lary C.} and Kitt, {Cheryl A.} and Elias Schwam and Beth Buckwald and Felix Garcia and Jerry Sepinwall and Price, {Donald L.}",

note = "Funding Information: The authors thank Drs. James Armstrong, Manuel F. Casanova, Linda C. Cork, Robert G. Struble, Peter J. Whitehouse and William Wooding, as well as Ms. Ninette Harris and Sharon DeVries for their contributions to this research. We are grateful to Drs. Ludwig A. and Nancy H. Sternberger for providing antineurofilament antibodies, to Ms. Eleanor Brown, Cynthia Jengeleski, Mary S. Lange and Lisabeth Raskin for technical assistance, and to Ms. Eileen McAuley for assistance in preparation of the manuscript. This work was supported by grants from the U.S. Public Health Service (NIH NS 20471, AG 05146, NS 07179, and AG 03359) and gifts from the Robert L. and Clara G. Patterson Trust and the Claster family.",

year = "1987",

doi = "10.1016/0197-4580(87)90067-4",

language = "English (US)",

volume = "8",

pages = "291--296",

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T1 - Senile plaques in aged squirrel monkeys

AU - Walker, Lary C.

AU - Kitt, Cheryl A.

AU - Schwam, Elias

AU - Buckwald, Beth

AU - Garcia, Felix

AU - Sepinwall, Jerry

AU - Price, Donald L.

N1 - Funding Information: The authors thank Drs. James Armstrong, Manuel F. Casanova, Linda C. Cork, Robert G. Struble, Peter J. Whitehouse and William Wooding, as well as Ms. Ninette Harris and Sharon DeVries for their contributions to this research. We are grateful to Drs. Ludwig A. and Nancy H. Sternberger for providing antineurofilament antibodies, to Ms. Eleanor Brown, Cynthia Jengeleski, Mary S. Lange and Lisabeth Raskin for technical assistance, and to Ms. Eileen McAuley for assistance in preparation of the manuscript. This work was supported by grants from the U.S. Public Health Service (NIH NS 20471, AG 05146, NS 07179, and AG 03359) and gifts from the Robert L. and Clara G. Patterson Trust and the Claster family.

PY - 1987

Y1 - 1987

N2 - Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.

AB - Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.

KW - Alzheimer's disease

KW - Amyloid Cytoskeleton

KW - Neuropeptide Y

KW - Primates

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Senile plaques in aged squirrel monkeys

Abstract

Keywords

ASJC Scopus subject areas

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