Senile plaques in aged squirrel monkeys

Lary C. Walker, Cheryl A. Kitt, Elias Schwam, Beth Buckwald, Felix Garcia, Jerry Sepinwall, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalNeurobiology of Aging
Volume8
Issue number4
DOIs
StatePublished - 1987

Fingerprint

Saimiri
Amyloid Plaques
Neurites
Temporal Lobe
Primates
Intermediate Filaments
Neuropeptide Y
Frontal Lobe
Amygdala
Macaca mulatta
Amyloid
Hippocampus
Antibodies
Brain

Keywords

  • Alzheimer's disease
  • Amyloid Cytoskeleton
  • Neuropeptide Y
  • Primates

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Walker, L. C., Kitt, C. A., Schwam, E., Buckwald, B., Garcia, F., Sepinwall, J., & Price, D. L. (1987). Senile plaques in aged squirrel monkeys. Neurobiology of Aging, 8(4), 291-296. https://doi.org/10.1016/0197-4580(87)90067-4

Senile plaques in aged squirrel monkeys. / Walker, Lary C.; Kitt, Cheryl A.; Schwam, Elias; Buckwald, Beth; Garcia, Felix; Sepinwall, Jerry; Price, Donald L.

In: Neurobiology of Aging, Vol. 8, No. 4, 1987, p. 291-296.

Research output: Contribution to journalArticle

Walker, LC, Kitt, CA, Schwam, E, Buckwald, B, Garcia, F, Sepinwall, J & Price, DL 1987, 'Senile plaques in aged squirrel monkeys', Neurobiology of Aging, vol. 8, no. 4, pp. 291-296. https://doi.org/10.1016/0197-4580(87)90067-4
Walker LC, Kitt CA, Schwam E, Buckwald B, Garcia F, Sepinwall J et al. Senile plaques in aged squirrel monkeys. Neurobiology of Aging. 1987;8(4):291-296. https://doi.org/10.1016/0197-4580(87)90067-4
Walker, Lary C. ; Kitt, Cheryl A. ; Schwam, Elias ; Buckwald, Beth ; Garcia, Felix ; Sepinwall, Jerry ; Price, Donald L. / Senile plaques in aged squirrel monkeys. In: Neurobiology of Aging. 1987 ; Vol. 8, No. 4. pp. 291-296.
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