Senescent cells and osteoarthritis: A painful connection

Ok Hee Jeon, Nathaniel David, Judith Campisi, Jennifer Hartt Elisseeff

Research output: Contribution to journalReview article

Abstract

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells' relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance. As part of their senescence-associated secretory phenotype, SnCs secrete cytokines that impact the immune system and its response to joint tissue trauma. We present concepts of the immune response to tissue trauma as well as the interactions with SnCs and the local tissue environment. Finally, we discuss therapeutic implications of targeting SnCs in treating osteoarthritis.

Original languageEnglish (US)
Pages (from-to)1229-1237
Number of pages9
JournalJournal of Clinical Investigation
Volume128
Issue number4
DOIs
StatePublished - Apr 2 2018

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Osteoarthritis
Joints
Cartilage
Wounds and Injuries
Prostheses and Implants
Arthritis
Immune System
Knee
Chronic Disease
Pathology
Cytokines
Inflammation
Phenotype
Pain
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Senescent cells and osteoarthritis : A painful connection. / Jeon, Ok Hee; David, Nathaniel; Campisi, Judith; Elisseeff, Jennifer Hartt.

In: Journal of Clinical Investigation, Vol. 128, No. 4, 02.04.2018, p. 1229-1237.

Research output: Contribution to journalReview article

Jeon, Ok Hee ; David, Nathaniel ; Campisi, Judith ; Elisseeff, Jennifer Hartt. / Senescent cells and osteoarthritis : A painful connection. In: Journal of Clinical Investigation. 2018 ; Vol. 128, No. 4. pp. 1229-1237.
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