Semaphorins: Mediators of repulsive growth cone guidance

Alex L. Kolodkin

doi:10.1016/0962-8924(96)81033-6

Semaphorins: Mediators of repulsive growth cone guidance

Alex L. Kolodkin

School of Medicine

Research output: Contribution to journal › Review article › peer-review

94 Scopus citations

Abstract

During development neuronal growth cones encounter a variety of guidance cues while mediating axon pathfinding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.

Original language	English (US)
Pages (from-to)	15-22
Number of pages	8
Journal	Trends in Cell Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0962-8924(96)81033-6
State	Published - Jan 1996

ASJC Scopus subject areas

Cell Biology

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10.1016/0962-8924(96)81033-6

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title = "Semaphorins: Mediators of repulsive growth cone guidance",

abstract = "During development neuronal growth cones encounter a variety of guidance cues while mediating axon pathfinding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.",

author = "Kolodkin, {Alex L.}",

note = "Funding Information: I thank A. Ghorpade for critical reading of the manuscript and J, Edwards for preparation of the figures. Work in the author{\textquoteright}s laboratory is supported by grants from the NIH (Al32890, Al37475 and RR1 1589).",

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PY - 1996/1

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N2 - During development neuronal growth cones encounter a variety of guidance cues while mediating axon pathfinding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.

AB - During development neuronal growth cones encounter a variety of guidance cues while mediating axon pathfinding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.

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Semaphorins: Mediators of repulsive growth cone guidance

Abstract

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