Semaphorins and the dynamic regulation of synapse assembly, refinement, and function

Eleftheria Koropouli, Alex L Kolodkin

Research output: Contribution to journalArticle

Abstract

Semaphorins are phylogenetically conserved proteins expressed in most organ systems, including the nervous system. Following their description as axon guidance cues, semaphorins have been implicated in multiple aspects of nervous system development. Semaphorins are key regulators of neural circuit assembly, neuronal morphogenesis, assembly of excitatory and inhibitory synapses, and synaptic refinement. Semaphorins contribute to the balance between excitatory and inhibitory synaptic transmission, and electrical activity can modulate semaphorin signaling in neurons. This interplay between guidance cue signaling and electrical activity has the potential to sculpt the wiring of neural circuits and to modulate their function.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume27
DOIs
StatePublished - Aug 2014

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Semaphorins
Synapses
Nervous System
Cues
Morphogenesis
Synaptic Transmission
Neurons
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Semaphorins and the dynamic regulation of synapse assembly, refinement, and function. / Koropouli, Eleftheria; Kolodkin, Alex L.

In: Current Opinion in Neurobiology, Vol. 27, 08.2014, p. 1-7.

Research output: Contribution to journalArticle

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