Semaphorin regulation of neural circuit assembly in the central nervous system

Randal Hand, Alex L Kolodkin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The assembly of neural circuits requires a wide array of molecular cues. These cues include secreted and transmembrane ligands and also the signaling receptors that together modulate axonal and dendritic morphology to promote functional neural connectivity during development. The semaphorin family of proteins and their various receptors serve this function. Many experiments demonstrate in vivo, and in multiple neural systems, how semaphorin-mediated regulation of neuronal morphology is critical for the regulation of neuronal connectivity. This system is nicely illustrated by recent work on semaphorin function in establishing neural connections in the olfactory and visual systems in both flies and mice. Further, semaphorins and their receptors regulate the elaboration of axon trajectories and precise targeting of these projections in the mammalian central nervous system, in addition to mediating axon pruning and also excitatory and inhibitory synaptogenesis. Taken together, these investigations into how semaphorins regulate neural connectivity provide insight into developmental mechanisms critical for neurite targeting, laminar-specific innervation, selective synapse formation, and neural circuit refinement.

Original languageEnglish (US)
Title of host publicationSemaphorins: A Diversity of Emerging Physiological and Pathological Activities
PublisherSpringer Japan
Pages19-38
Number of pages20
ISBN (Print)9784431543855, 9784431543848
DOIs
StatePublished - Jan 1 2015

Fingerprint

Semaphorins
Neurology
central nervous system
Central Nervous System
axons
receptors
Networks (circuits)
neurites
Cues
synapse
innervation
pruning
trajectories
Neuronal Plasticity
Neurites
Diptera
Synapses
mice
Axons
Trajectories

Keywords

  • Axon guidance
  • Cerebral cortex
  • Dendritic morphology
  • Hippocampus
  • Neural circuits
  • Neural development
  • Olfactory system
  • Plexin
  • Semaphorin
  • Visual system

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hand, R., & Kolodkin, A. L. (2015). Semaphorin regulation of neural circuit assembly in the central nervous system. In Semaphorins: A Diversity of Emerging Physiological and Pathological Activities (pp. 19-38). Springer Japan. https://doi.org/10.1007/978-4-431-54385-5_2

Semaphorin regulation of neural circuit assembly in the central nervous system. / Hand, Randal; Kolodkin, Alex L.

Semaphorins: A Diversity of Emerging Physiological and Pathological Activities. Springer Japan, 2015. p. 19-38.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hand, R & Kolodkin, AL 2015, Semaphorin regulation of neural circuit assembly in the central nervous system. in Semaphorins: A Diversity of Emerging Physiological and Pathological Activities. Springer Japan, pp. 19-38. https://doi.org/10.1007/978-4-431-54385-5_2
Hand R, Kolodkin AL. Semaphorin regulation of neural circuit assembly in the central nervous system. In Semaphorins: A Diversity of Emerging Physiological and Pathological Activities. Springer Japan. 2015. p. 19-38 https://doi.org/10.1007/978-4-431-54385-5_2
Hand, Randal ; Kolodkin, Alex L. / Semaphorin regulation of neural circuit assembly in the central nervous system. Semaphorins: A Diversity of Emerging Physiological and Pathological Activities. Springer Japan, 2015. pp. 19-38
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