TY - JOUR
T1 - Semaphorin junction
T2 - Making tracks toward neural connectivity
AU - Pasterkamp, R. Jeroen
AU - Kolodkin, Alex L.
N1 - Funding Information:
We gratefully acknowledge support for our work from The Netherlands Organization for Scientific Research and The Human Frontier Science Programme Organization (RJ Pasterkamp); The Kirsch Foundation, The Robert Packard Center for Amyotrophic Lateral Sclerosis Research at the Johns Hopkins University, the National Institutes of Neurological Disease and Stroke and the National Institute of Mental Health at the National Institutes of Health (AL Kolodkin).
PY - 2003/2
Y1 - 2003/2
N2 - Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.
AB - Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.
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U2 - 10.1016/S0959-4388(03)00003-5
DO - 10.1016/S0959-4388(03)00003-5
M3 - Review article
C2 - 12593985
AN - SCOPUS:0037320703
SN - 0959-4388
VL - 13
SP - 79
EP - 89
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -