Semaphorin junction: Making tracks toward neural connectivity

R. Jeroen Pasterkamp, Alex L Kolodkin

Research output: Contribution to journalArticle

Abstract

Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.

Original languageEnglish (US)
Pages (from-to)79-89
Number of pages11
JournalCurrent Opinion in Neurobiology
Volume13
Issue number1
DOIs
StatePublished - Feb 2003

Fingerprint

Semaphorins
Growth Cones
Actin Cytoskeleton
Actins
Signal Transduction
Ligands
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Semaphorin junction : Making tracks toward neural connectivity. / Pasterkamp, R. Jeroen; Kolodkin, Alex L.

In: Current Opinion in Neurobiology, Vol. 13, No. 1, 02.2003, p. 79-89.

Research output: Contribution to journalArticle

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