Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

Chenghua Gu, Yutaka Yoshida, Jean Livet, Dorothy V. Reimert, Fanny Mann, Janna Merte, Christopher E. Henderson, Thomas M. Jessell, Alex L. Kolodkin, David D. Ginty

Research output: Contribution to journalArticlepeer-review

Abstract

The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent intersomitic vessels. Sema3E-plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalScience
Volume307
Issue number5707
DOIs
StatePublished - Jan 14 2005

ASJC Scopus subject areas

  • General

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