Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

Chenghua Gu, Yutaka Yoshida, Jean Livet, Dorothy V. Reimert, Fanny Mann, Janna Merte, Christopher E. Henderson, Thomas M. Jessell, Alex L Kolodkin, David D. Ginty

Research output: Contribution to journalArticle

Abstract

The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent intersomitic vessels. Sema3E-plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalScience
Volume307
Issue number5707
DOIs
StatePublished - Jan 14 2005

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Neuropilins
Semaphorins
Blood Vessels
Endothelial Cells
Somites
Organogenesis
Cues
plexin

ASJC Scopus subject areas

  • General

Cite this

Gu, C., Yoshida, Y., Livet, J., Reimert, D. V., Mann, F., Merte, J., ... Ginty, D. D. (2005). Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science, 307(5707), 265-268. https://doi.org/10.1126/science.1105416

Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. / Gu, Chenghua; Yoshida, Yutaka; Livet, Jean; Reimert, Dorothy V.; Mann, Fanny; Merte, Janna; Henderson, Christopher E.; Jessell, Thomas M.; Kolodkin, Alex L; Ginty, David D.

In: Science, Vol. 307, No. 5707, 14.01.2005, p. 265-268.

Research output: Contribution to journalArticle

Gu, C, Yoshida, Y, Livet, J, Reimert, DV, Mann, F, Merte, J, Henderson, CE, Jessell, TM, Kolodkin, AL & Ginty, DD 2005, 'Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins', Science, vol. 307, no. 5707, pp. 265-268. https://doi.org/10.1126/science.1105416
Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J et al. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-268. https://doi.org/10.1126/science.1105416
Gu, Chenghua ; Yoshida, Yutaka ; Livet, Jean ; Reimert, Dorothy V. ; Mann, Fanny ; Merte, Janna ; Henderson, Christopher E. ; Jessell, Thomas M. ; Kolodkin, Alex L ; Ginty, David D. / Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. In: Science. 2005 ; Vol. 307, No. 5707. pp. 265-268.
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