Semantic association fMRI impairments represent a potential schizophrenia biomarker

Sharna D. Jamadar, Godfrey D. Pearlson, Kasey M. O'Neil, Michal Assaf

Research output: Contribution to journalArticle

Abstract

Semantic association retrieval task (SORT) requires participants to indicate whether word pairs recall a third object, e.g. 'honey' and 'stings' activates 'bees'. We have previously shown that individuals with schizophrenia with more severe positive symptoms tend to report associations between unrelated word pairs than healthy controls; schizophrenia individuals with more severe negative symptoms tend to fail to report associations between related word pairs. This over-retrieval and under-retrieval on SORT correlates with functional magnetic resonance imaging (fMRI) activity in inferior parietal lobule (IPL). To examine the suitability of SORT as an endophenotype for schizophrenia, we examined SORT performance and activity across multiple stages of the illness: chronic, relapse, and first episode. We also examine SORT performance and activity in unaffected relatives. SORT performance and fMRI activity in schizophrenia-first episode, schizophrenia-chronic and schizophrenia-relapse were significantly impaired relative to healthy controls and unaffected relatives. Schizophrenia-chronic and schizophrenia-relapse participants showing more severe PANSS-positive and -general symptoms showed larger SORT impairments. For schizophrenia-first episode more severe negative symptoms were related to lower IPL activation, consistent with previous results showing that negative symptoms are among the first to emerge in the schizophrenia prodrome and that more severe symptoms in the first episode predict worse future outcomes. Unaffected relatives showed no impairments on SORT performance or fMRI activity relative to healthy controls, which is incompatible with the concept of SORT as an endophenotype for schizophrenia, but is consistent with the concept of SORT as a potential schizophrenia biomarker.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalSchizophrenia Research
Volume145
Issue number1-3
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Semantics
Schizophrenia
Biomarkers
Magnetic Resonance Imaging
Endophenotypes
Parietal Lobe
Recurrence
Honey
Bees
Bites and Stings

Keywords

  • Biomarker
  • FMRI
  • Formal thought disorder
  • Positive and negative symptoms
  • Semantic association

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Semantic association fMRI impairments represent a potential schizophrenia biomarker. / Jamadar, Sharna D.; Pearlson, Godfrey D.; O'Neil, Kasey M.; Assaf, Michal.

In: Schizophrenia Research, Vol. 145, No. 1-3, 04.2013, p. 20-26.

Research output: Contribution to journalArticle

Jamadar, Sharna D. ; Pearlson, Godfrey D. ; O'Neil, Kasey M. ; Assaf, Michal. / Semantic association fMRI impairments represent a potential schizophrenia biomarker. In: Schizophrenia Research. 2013 ; Vol. 145, No. 1-3. pp. 20-26.
@article{211de9bae7604b39ab8fe2782b2786c2,
title = "Semantic association fMRI impairments represent a potential schizophrenia biomarker",
abstract = "Semantic association retrieval task (SORT) requires participants to indicate whether word pairs recall a third object, e.g. 'honey' and 'stings' activates 'bees'. We have previously shown that individuals with schizophrenia with more severe positive symptoms tend to report associations between unrelated word pairs than healthy controls; schizophrenia individuals with more severe negative symptoms tend to fail to report associations between related word pairs. This over-retrieval and under-retrieval on SORT correlates with functional magnetic resonance imaging (fMRI) activity in inferior parietal lobule (IPL). To examine the suitability of SORT as an endophenotype for schizophrenia, we examined SORT performance and activity across multiple stages of the illness: chronic, relapse, and first episode. We also examine SORT performance and activity in unaffected relatives. SORT performance and fMRI activity in schizophrenia-first episode, schizophrenia-chronic and schizophrenia-relapse were significantly impaired relative to healthy controls and unaffected relatives. Schizophrenia-chronic and schizophrenia-relapse participants showing more severe PANSS-positive and -general symptoms showed larger SORT impairments. For schizophrenia-first episode more severe negative symptoms were related to lower IPL activation, consistent with previous results showing that negative symptoms are among the first to emerge in the schizophrenia prodrome and that more severe symptoms in the first episode predict worse future outcomes. Unaffected relatives showed no impairments on SORT performance or fMRI activity relative to healthy controls, which is incompatible with the concept of SORT as an endophenotype for schizophrenia, but is consistent with the concept of SORT as a potential schizophrenia biomarker.",
keywords = "Biomarker, FMRI, Formal thought disorder, Positive and negative symptoms, Semantic association",
author = "Jamadar, {Sharna D.} and Pearlson, {Godfrey D.} and O'Neil, {Kasey M.} and Michal Assaf",
year = "2013",
month = "4",
doi = "10.1016/j.schres.2012.12.029",
language = "English (US)",
volume = "145",
pages = "20--26",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Semantic association fMRI impairments represent a potential schizophrenia biomarker

AU - Jamadar, Sharna D.

AU - Pearlson, Godfrey D.

AU - O'Neil, Kasey M.

AU - Assaf, Michal

PY - 2013/4

Y1 - 2013/4

N2 - Semantic association retrieval task (SORT) requires participants to indicate whether word pairs recall a third object, e.g. 'honey' and 'stings' activates 'bees'. We have previously shown that individuals with schizophrenia with more severe positive symptoms tend to report associations between unrelated word pairs than healthy controls; schizophrenia individuals with more severe negative symptoms tend to fail to report associations between related word pairs. This over-retrieval and under-retrieval on SORT correlates with functional magnetic resonance imaging (fMRI) activity in inferior parietal lobule (IPL). To examine the suitability of SORT as an endophenotype for schizophrenia, we examined SORT performance and activity across multiple stages of the illness: chronic, relapse, and first episode. We also examine SORT performance and activity in unaffected relatives. SORT performance and fMRI activity in schizophrenia-first episode, schizophrenia-chronic and schizophrenia-relapse were significantly impaired relative to healthy controls and unaffected relatives. Schizophrenia-chronic and schizophrenia-relapse participants showing more severe PANSS-positive and -general symptoms showed larger SORT impairments. For schizophrenia-first episode more severe negative symptoms were related to lower IPL activation, consistent with previous results showing that negative symptoms are among the first to emerge in the schizophrenia prodrome and that more severe symptoms in the first episode predict worse future outcomes. Unaffected relatives showed no impairments on SORT performance or fMRI activity relative to healthy controls, which is incompatible with the concept of SORT as an endophenotype for schizophrenia, but is consistent with the concept of SORT as a potential schizophrenia biomarker.

AB - Semantic association retrieval task (SORT) requires participants to indicate whether word pairs recall a third object, e.g. 'honey' and 'stings' activates 'bees'. We have previously shown that individuals with schizophrenia with more severe positive symptoms tend to report associations between unrelated word pairs than healthy controls; schizophrenia individuals with more severe negative symptoms tend to fail to report associations between related word pairs. This over-retrieval and under-retrieval on SORT correlates with functional magnetic resonance imaging (fMRI) activity in inferior parietal lobule (IPL). To examine the suitability of SORT as an endophenotype for schizophrenia, we examined SORT performance and activity across multiple stages of the illness: chronic, relapse, and first episode. We also examine SORT performance and activity in unaffected relatives. SORT performance and fMRI activity in schizophrenia-first episode, schizophrenia-chronic and schizophrenia-relapse were significantly impaired relative to healthy controls and unaffected relatives. Schizophrenia-chronic and schizophrenia-relapse participants showing more severe PANSS-positive and -general symptoms showed larger SORT impairments. For schizophrenia-first episode more severe negative symptoms were related to lower IPL activation, consistent with previous results showing that negative symptoms are among the first to emerge in the schizophrenia prodrome and that more severe symptoms in the first episode predict worse future outcomes. Unaffected relatives showed no impairments on SORT performance or fMRI activity relative to healthy controls, which is incompatible with the concept of SORT as an endophenotype for schizophrenia, but is consistent with the concept of SORT as a potential schizophrenia biomarker.

KW - Biomarker

KW - FMRI

KW - Formal thought disorder

KW - Positive and negative symptoms

KW - Semantic association

UR - http://www.scopus.com/inward/record.url?scp=84875273587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875273587&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2012.12.029

DO - 10.1016/j.schres.2012.12.029

M3 - Article

C2 - 23403412

AN - SCOPUS:84875273587

VL - 145

SP - 20

EP - 26

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -