Semantic activation and implicit memory in Alzheimer disease.

J. Brandt, M. Spencer, P. McSorley, M. F. Folstein

Research output: Contribution to journalArticle

Abstract

Patients with Alzheimer disease (AD) invariably display pronounced deficits in verbal memory when retention is tested explicitly. The present study examined the possibility that tasks which require memory only implicitly would be performed normally. Moderately demented patients with probable AD were severely impaired in free recall of a word list. On a subsequent word association test, the AD patients were less likely than normals to give items from the recall list as their word associations. The results suggest that implicit verbal memory, as well as explicit memory, is impaired in AD. While the magnitude of the activation effect was significantly reduced in AD patients, it was uncorrelated with recall performance or a measure of global cognitive functioning. Memory activation may thus depend on neural circuitry outside the traditional (i.e. temporo-limbic) memory system.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalAlzheimer disease and associated disorders
Volume2
Issue number2
DOIs
StatePublished - 1988

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ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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