Self-termination/anergic mechanisms in human basophils and mast cells

Research output: Contribution to journalReview article


All cellular reactions include feedback loops, both positive and negative. Following all receptor-mediated stimulation there are events that activate the cell response and events that dampen the receptor response back to resting conditions. IgE-mediated activation of mast cells and basophils necessarily includes a variety of signaling events that serve to terminate the activation processes. Some of these negative feedback loops are active even in resting cells and likely serve to establish a set point for the cell's response to IgE-mediated stimulation. But many negative feedback loops become active only after the cell is stimulated. By and large, it will be these processes that will be discussed in this review.

Original languageEnglish (US)
Pages (from-to)109-121
Number of pages13
JournalInternational Archives of Allergy and Immunology
Issue number2
StatePublished - Sep 1 2009



  • Anergy
  • Basophil activation
  • Basophils
  • Desensitization
  • Fc receptor (high-affinity IgE receptor)
  • Human
  • Mast cell
  • Regulation
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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