TY - JOUR
T1 - Self-reports of medication side effects and pain-related activity interference in patients with chronic pain
T2 - A longitudinal cohort study
AU - Martel, Marc O.
AU - Finan, Patrick H.
AU - Dolman, Andrew J.
AU - Subramanian, Subu
AU - Edwards, Robert R.
AU - Wasan, Ajay D.
AU - Jamison, Robert N.
N1 - Publisher Copyright:
© 2015 International Association for the Study of Pain.
PY - 2015
Y1 - 2015
N2 - The primary purpose of this study was to examine the association between self-reports of medication side effects and pain-related activity interference in patients with chronic pain. The potential moderators of the association between reports of side effects and pain-related activity interference were also examined. A total of 111 patients with chronic musculoskeletal pain were asked to provide, once a month for a period of 6 months, self-reports of medication use and the presence of any perceived side effects (eg, nausea, dizziness, headaches) associated with their medications. At each of these time points, patients were also asked to provide self-reports of pain intensity, negative affect, and pain-related activity interference. Multilevel modeling analyses revealed that month-to-month increases in perceived medication side effects were associated with heightened pain-related activity interference (P < 0.05). Importantly, multilevel models revealed that perceived medication side effects were associated with heightened painrelated activity interference even after controlling for the influence of patient demographics, pain intensity, and negative affect. This study provides preliminary evidence that reports of medication side effects are associated with heightened pain-related activity interference in patients with chronic pain beyond the influence of other pain-relevant variables. The implications of our findings for clinical practice and the management of patients with chronic pain conditions are discussed.
AB - The primary purpose of this study was to examine the association between self-reports of medication side effects and pain-related activity interference in patients with chronic pain. The potential moderators of the association between reports of side effects and pain-related activity interference were also examined. A total of 111 patients with chronic musculoskeletal pain were asked to provide, once a month for a period of 6 months, self-reports of medication use and the presence of any perceived side effects (eg, nausea, dizziness, headaches) associated with their medications. At each of these time points, patients were also asked to provide self-reports of pain intensity, negative affect, and pain-related activity interference. Multilevel modeling analyses revealed that month-to-month increases in perceived medication side effects were associated with heightened pain-related activity interference (P < 0.05). Importantly, multilevel models revealed that perceived medication side effects were associated with heightened painrelated activity interference even after controlling for the influence of patient demographics, pain intensity, and negative affect. This study provides preliminary evidence that reports of medication side effects are associated with heightened pain-related activity interference in patients with chronic pain beyond the influence of other pain-relevant variables. The implications of our findings for clinical practice and the management of patients with chronic pain conditions are discussed.
KW - Chronic pain
KW - Medication side effects
KW - Negative affect
KW - Pain-related activity interference
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U2 - 10.1097/j.pain.0000000000000154
DO - 10.1097/j.pain.0000000000000154
M3 - Article
C2 - 25782367
AN - SCOPUS:85013482380
SN - 0304-3959
VL - 156
SP - 1092
EP - 1100
JO - Pain
JF - Pain
IS - 6
ER -