Self-reported exercise and longitudinal outcomes in cystic fibrosis: A retrospective cohort study

Joseph M. Collaco, Scott M. Blackman, Karen S. Raraigh, Christopher B. Morrow, Garry R. Cutting, Shruti M. Paranjape

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cystic fibrosis (CF) is characterized by recurrent respiratory infections and progressive lung disease. Whereas exercise may contribute to preserving lung function, its benefit is difficult to ascertain given the selection bias of healthier patients being more predisposed to exercise. Our objective was to examine the role of self-reported exercise with longitudinal lung function and body mass index (BMI) measures in CF.Methods: A total of 1038 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine exercise habits. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes.Results: Within the study sample 75% of subjects self-reported regular exercise. Exercise was associated with an older age of diagnosis (p = 0.002), older age at the time of ascertainment (p < 0.001), and higher baseline FEV1 (p = 0.001), but not CFTR genotype (p = 0.64) or exocrine pancreatic function (p = 0.19). In adjusted mixed models, exercise was associated with both a reduced decline in FEV1 (p < 0.001) and BMI Z-score (p = 0.001) for adults, but not children aged 10-17 years old.Conclusions: In our retrospective study, self-reported exercise was associated with improved longitudinal nutritional and pulmonary outcomes in cystic fibrosis for adults. Although prospective studies are needed to confirm these associations, programs to promote regular exercise among individuals with cystic fibrosis would be beneficial.

Original languageEnglish (US)
Article number159
JournalBMC pulmonary medicine
Volume14
Issue number1
DOIs
StatePublished - Oct 6 2014

Keywords

  • Body mass index
  • Cystic fibrosis
  • Exercise
  • FEV1
  • Lung function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Self-reported exercise and longitudinal outcomes in cystic fibrosis: A retrospective cohort study'. Together they form a unique fingerprint.

Cite this