TY - JOUR
T1 - Self-reported exercise and longitudinal outcomes in cystic fibrosis
T2 - A retrospective cohort study
AU - Collaco, Joseph M.
AU - Blackman, Scott M.
AU - Raraigh, Karen S.
AU - Morrow, Christopher B.
AU - Cutting, Garry R.
AU - Paranjape, Shruti M.
N1 - Funding Information:
This work was supported by grants from the Cystic Fibrosis Foundation, Gilead Sciences Inc., and the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation. All authors disclose that they have no financial interests in the subject of this manuscript. The authors declare that they have no competing interests.
Publisher Copyright:
© 2014 Collaco et al.; licensee BioMed Central Ltd.
PY - 2014/10/6
Y1 - 2014/10/6
N2 - Background: Cystic fibrosis (CF) is characterized by recurrent respiratory infections and progressive lung disease. Whereas exercise may contribute to preserving lung function, its benefit is difficult to ascertain given the selection bias of healthier patients being more predisposed to exercise. Our objective was to examine the role of self-reported exercise with longitudinal lung function and body mass index (BMI) measures in CF.Methods: A total of 1038 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine exercise habits. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes.Results: Within the study sample 75% of subjects self-reported regular exercise. Exercise was associated with an older age of diagnosis (p = 0.002), older age at the time of ascertainment (p < 0.001), and higher baseline FEV1 (p = 0.001), but not CFTR genotype (p = 0.64) or exocrine pancreatic function (p = 0.19). In adjusted mixed models, exercise was associated with both a reduced decline in FEV1 (p < 0.001) and BMI Z-score (p = 0.001) for adults, but not children aged 10-17 years old.Conclusions: In our retrospective study, self-reported exercise was associated with improved longitudinal nutritional and pulmonary outcomes in cystic fibrosis for adults. Although prospective studies are needed to confirm these associations, programs to promote regular exercise among individuals with cystic fibrosis would be beneficial.
AB - Background: Cystic fibrosis (CF) is characterized by recurrent respiratory infections and progressive lung disease. Whereas exercise may contribute to preserving lung function, its benefit is difficult to ascertain given the selection bias of healthier patients being more predisposed to exercise. Our objective was to examine the role of self-reported exercise with longitudinal lung function and body mass index (BMI) measures in CF.Methods: A total of 1038 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine exercise habits. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes.Results: Within the study sample 75% of subjects self-reported regular exercise. Exercise was associated with an older age of diagnosis (p = 0.002), older age at the time of ascertainment (p < 0.001), and higher baseline FEV1 (p = 0.001), but not CFTR genotype (p = 0.64) or exocrine pancreatic function (p = 0.19). In adjusted mixed models, exercise was associated with both a reduced decline in FEV1 (p < 0.001) and BMI Z-score (p = 0.001) for adults, but not children aged 10-17 years old.Conclusions: In our retrospective study, self-reported exercise was associated with improved longitudinal nutritional and pulmonary outcomes in cystic fibrosis for adults. Although prospective studies are needed to confirm these associations, programs to promote regular exercise among individuals with cystic fibrosis would be beneficial.
KW - Body mass index
KW - Cystic fibrosis
KW - Exercise
KW - FEV1
KW - Lung function
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U2 - 10.1186/1471-2466-14-159
DO - 10.1186/1471-2466-14-159
M3 - Article
C2 - 25287419
AN - SCOPUS:84908071617
SN - 1471-2466
VL - 14
JO - BMC pulmonary medicine
JF - BMC pulmonary medicine
IS - 1
M1 - 159
ER -