Self-reported body fat change in HIV-infected men is a marker of decline in physical health-related quality of life with aging, independent of co-morbidity

Kristine M. Erlandson, Sandra M. Reynolds, Christopher Cox, Frank J. Palella, Mallory D. Witt, Lawrence A. Kingsley, Todd T Brown, Michael Plankey

Research output: Contribution to journalArticle

Abstract

Objective: Self-perception of changes in body fat among HIV+ persons is associated with decreased health related quality of life in cross-sectional studies. The longitudinal impact of body fat changes on health related quality of life, while accounting for comorbidity and anatomic location or severity of body fat changes, is unknown. Design: This was a longitudinal analysis of HIV+ and HIV- Multicenter AIDS Cohort Study (MACS) participants who completed questionnaires assessing self-perceived body fat changes (baseline visit) and a health related quality of life (Short Form-36) at baseline and then ≥5 years later. Methods: Relationships between body fat changes and change in Short Form-36 Physical and Mental Component Summary scores were investigated using mixedmodel regression. Results: We studied 270 HIV+ and 247 HIV- men. At baseline, ≥50% of HIV+ men reported body fat changes; physical component but not mental component summary scores were lower among HIV+ men who reported moderate/severe leg or abdominal fat changes (p

Original languageEnglish (US)
Article numbere114166
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2014

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quality of life
body fat
Adipose Tissue
Aging of materials
Fats
Quality of Life
Health
HIV
Morbidity
self-perception
Abdominal Fat
abdominal fat
cohort studies
cross-sectional studies
comorbidity
Self Concept
legs
questionnaires
Comorbidity
Leg

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Self-reported body fat change in HIV-infected men is a marker of decline in physical health-related quality of life with aging, independent of co-morbidity. / Erlandson, Kristine M.; Reynolds, Sandra M.; Cox, Christopher; Palella, Frank J.; Witt, Mallory D.; Kingsley, Lawrence A.; Brown, Todd T; Plankey, Michael.

In: PLoS One, Vol. 9, No. 12, e114166, 01.12.2014.

Research output: Contribution to journalArticle

Erlandson, Kristine M. ; Reynolds, Sandra M. ; Cox, Christopher ; Palella, Frank J. ; Witt, Mallory D. ; Kingsley, Lawrence A. ; Brown, Todd T ; Plankey, Michael. / Self-reported body fat change in HIV-infected men is a marker of decline in physical health-related quality of life with aging, independent of co-morbidity. In: PLoS One. 2014 ; Vol. 9, No. 12.
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